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New data identify an increasing sex ratio of multiple sclerosis in Sweden
Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences.
Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology. Östergötlands Läns Landsting, Local Health Care Services in West Östergötland, Department of Medical Specialist in Motala.
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2014 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 20, no 12, 1578-1583 p.Article in journal (Refereed) Published
Abstract [en]

Background: An increasing women-to-men ratio in later birth cohorts of patients with multiple sclerosis (MS) has been observed in several populations and has been hypothesised to be due to one or several environmental factors of importance for disease aetiology. However, in a study based on data from the Swedish MS registry (SMSreg) this ratio was recently reported to be rather stable during the 20th century. Objective: The purpose of this study was to reinvestigate the women-to-men ratio in Sweden based on data from all available data sources, including deceased patients. Method: We combined data from the SMSreg with data from national patient registers. Results: In total we obtained information on 19,510 MS patients born 1931-1985, 13,321 women and 6189 men. The women-to-men ratio increased from 1.70 for patients born in the 1930s to 2.67 for patients born in the 1980s. When comparing the coverage of SMSreg to the full data set, a significantly higher proportion of women born 1931-1935 compared to men born in the same period were found in SMSreg, resulting in a sampling bias hiding the increasing sex ratio in the full material. Conclusion: The women-to-men ratio in MS has increased in Sweden during the 20th century similarly to observations in other western countries.

Place, publisher, year, edition, pages
SAGE Publications (UK and US) , 2014. Vol. 20, no 12, 1578-1583 p.
Keyword [en]
Multiple sclerosis; sex ratio; epidemiology; prevalence proportion; register study
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-112652DOI: 10.1177/1352458514530021ISI: 000344136400006PubMedID: 24842964OAI: oai:DiVA.org:liu-112652DiVA: diva2:768927
Note

Funding Agencies|Swedish Research Council; Bibbi and Nils Jensen Foundation; Swedish Foundation for Strategic Research; Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) [340-2013-5867]

Available from: 2014-12-05 Created: 2014-12-05 Last updated: 2017-12-05

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Boström, IngerLandtblom, Anne-Marie

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Boström, IngerLandtblom, Anne-Marie
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Division of NeuroscienceFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of NeurologyDepartment of Medical Specialist in Motala
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Multiple Sclerosis
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