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Impaired metabolic control and socio-demographic status in immigrant children at onset of Type 1 diabetes
University of Örebro, Sweden; Uppsala University, Sweden; Malarsjukhuset Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Uppsala University, Sweden.
University of Örebro, Sweden; Örebro University Hospital, Sweden.
2014 (English)In: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 31, no 11, 1418-1423 p.Article in journal (Refereed) Published
Abstract [en]

AimThe aim of the present study was to compare clinical and socio-demographic conditions at the onset of Type1 diabetes in children born to immigrant families and children born to Swedish families, and to assess whether those conditions had an impact on metabolic status. Methods and designThis was an observational nationwide population-based matched cohort study on prospectively recorded registry data of all children with diabetes in Sweden and their families during 2000-2010. Out of a total of 13415 children from the Swedish Childhood Diabetes Registry (SWEDIABKIDS), 879 children born to immigrant parents were collected. To these we added 2627 children with Swedish-born parents, matched for gender, age and year of onset of Type1 diabetes. ResultsThe proportion of low capillary pH (less than7.30) at onset was higher in the immigrant cohort [25.8% vs. 16.4% in the Swedish cohort (Pless than0.001)]. HbA(1c) was also higher [95mmol/mol (10.8%) vs. 88mmol/mol (10.2%), respectively (Pless than0.001)]. In a logistic regression model with low pH as the dependent variable, we were unable to reveal any significant association to socio-demographic factors, but the odds ratio for HbA(1c) was 0.983 (95%CI 0.976-0.991) and for plasma glucose was 0.953 (95%CI 0.933-0.973). ConclusionChildren born to immigrant parents have lower capillary pH and higher HbA(1c) at diabetes onset. Immigrant families harbour lower socio-demographic living conditions, but this fact does not seem to influence the inferior metabolic condition at diabetes onset.

Place, publisher, year, edition, pages
Wiley , 2014. Vol. 31, no 11, 1418-1423 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-112622DOI: 10.1111/dme.12511ISI: 000344010200020PubMedID: 24861156OAI: diva2:769569

Funding Agencies|Centre for Clinical Research Sormland, Uppsala University, Sweden; Swedish Child Diabetes Foundation (Barndiabetesfonden), Linkoping, Sweden

Available from: 2014-12-08 Created: 2014-12-05 Last updated: 2015-01-07

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Samuelsson, Ulf
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in Linköping
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