Genetic variations of NLRP1: susceptibility in psoriasis
2014 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 171, no 6, 1517-1520 p.Article in journal (Refereed) Published
BACKGROUND: NACHT, LRR and PYD domain-containing protein (NLRP)1 is part of the inflammasome multiprotein complex involved in the production of interleukin (IL)-1β and IL-18, two cytokines strongly implicated in psoriasis pathogenesis. Genetic variations in NLRP1 are associated with a predisposition for chronic inflammatory conditions.
OBJECTIVES: The aim of the study was to investigate the role of genetic variation in the NLRP1 inflammasome in psoriasis susceptibility.
MATERIAL AND METHODS: Four haplotype-tagging single-nucleotide polymorphisms (SNPs) (rs6502867, rs8079034, rs878329 and rs12150220) were investigated by TaqMan allelic discrimination in a patient sample comprising 1847 individuals from 478 families and 802 healthy controls.
RESULTS: Using the transmission disequilibrium test, a significant increase in the transmission of the NLRP1 rs8079034C and rs878329C alleles to patients with psoriasis was demonstrated (P = 0·006 and P = 0·033, respectively). Furthermore, homozygosity for the rs878329C allele correlated with a younger age of onset. We also observed an increase in the expression of NLRP1 mRNA in the peripheral blood cells of patients with psoriasis. This was accompanied by a higher level of circulating IL-18 and appeared to be associated with the rs878329C allele.
CONCLUSIONS: Our data support the involvement of NLRP1 and the NLRP1 inflammasome in psoriasis susceptibility and further support the role of innate immunity in psoriasis.
Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 171, no 6, 1517-1520 p.
Clinical Medicine Basic Medicine
IdentifiersURN: urn:nbn:se:liu:diva-112730DOI: 10.1111/bjd.13178ISI: 000347236100197PubMedID: 24909542OAI: oai:DiVA.org:liu-112730DiVA: diva2:770335
The study was funded by the Ingrid Asp foundation, the Welander Foundation and the Swedish Psoriasis Association.2014-12-102014-12-102015-10-16Bibliographically approved