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Pulse wave velocity with 4D flow MRI: Systematic differences and age-related regional vascular stiffness
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-1395-8296
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-9095-403X
2014 (English)In: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 32, no 10, 1266-1271 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: The objective of this study was to compare multiple methods for estimation of PWV from 4D flow MRI velocity data and to investigate if 4D flow MRI-based PWV estimation with piecewise linear regression modeling of travel-distance vs. travel time is sufficient to discern age-related regional differences in PWV. Methods: 4D flow MRI velocity data were acquired in 8 young and Solder (age: 23 +/- 2 vs. 58 +/- 2 years old) normal volunteers. Travel-time and travel-distance were measured throughout the aorta and piecewise linear regression was used to measure global PWV in the descending aorta and regional PWV in three equally sized segments between the top of the aortic arch and the renal arteries. Six different methods for extracting travel-time were compared. Results: Methods for estimation of travel-time that use information about the whole flow waveform systematically overestimate PWV when compared to methods restricted to the upslope-portion of the waveforms (p less than 0.05). In terms of regional PWV, a significant interaction was found between age and location (p less than 0.05). The age-related differences in regional PWV were greater in the proximal compared to distal descending aorta. Conclusion: Care must be taken as different classes of methods for the estimation of travel-time produce different results. 4D flow MRI-based PWV estimation with piecewise linear regression modeling of travel-distance vs. travel time can discern age-related differences in regional PWV well in line with previously reported data.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 32, no 10, 1266-1271 p.
Keyword [en]
Pulse wave velocity; MR flow imaging; Vascular stiffness; 4D flow MRI; Phase-contrast MRI; Aging
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-112805DOI: 10.1016/j.mri.2014.08.021ISI: 000344721800014PubMedID: 25171817OAI: oai:DiVA.org:liu-112805DiVA: diva2:777205
Note

Funding Agencies|Swedish Research Council; Swedish Heart-Lung Foundation; Medical Research Council of Southeast Sweden (FORSS)

Available from: 2015-01-08 Created: 2014-12-17 Last updated: 2017-12-05

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Dyverfeldt, PetterEbbers, TinoLänne, Toste

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Division of Cardiovascular MedicineFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in LinköpingDepartment of Thoracic and Vascular Surgery
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