A study of amikacin given once versus twice daily in serious infections.
1988 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 22, no 1, 75-79 p.Article in journal (Refereed) Published
Forty-five mostly elderly patients with serious infections were treated in a prospective, comparative and randomized pharmacokinetic study with amikacin 11.0 or 15.0 mg/kg administered in a single daily dose as an intravenous, short-term infusion or with amikacin 7.5 mg/kg administered twice daily in the same way. The results indicate that administration of amikacin 15 mg/kg in a single daily dose should be a practical and safe principle of administration. However elderly patients often have reduced creatinine clearance and should preferably be given a lower dose of 11 mg/kg bw. The risk of nephrotoxicity did not increase, but conclusions on ototoxicity and clinical efficacy cannot be drawn from this limited study. This should be considered as an initial part of a future multicentre trial.
Place, publisher, year, edition, pages
1988. Vol. 22, no 1, 75-79 p.
IdentifiersURN: urn:nbn:se:liu:diva-112434DOI: 10.1093/jac/22.1.75PubMedID: 3170393OAI: oai:DiVA.org:liu-112434DiVA: diva2:777371