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A study of amikacin given once versus twice daily in serious infections.
Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
1988 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 22, no 1, 75-79 p.Article in journal (Refereed) Published
Abstract [en]

Forty-five mostly elderly patients with serious infections were treated in a prospective, comparative and randomized pharmacokinetic study with amikacin 11.0 or 15.0 mg/kg administered in a single daily dose as an intravenous, short-term infusion or with amikacin 7.5 mg/kg administered twice daily in the same way. The results indicate that administration of amikacin 15 mg/kg in a single daily dose should be a practical and safe principle of administration. However elderly patients often have reduced creatinine clearance and should preferably be given a lower dose of 11 mg/kg bw. The risk of nephrotoxicity did not increase, but conclusions on ototoxicity and clinical efficacy cannot be drawn from this limited study. This should be considered as an initial part of a future multicentre trial.

Place, publisher, year, edition, pages
1988. Vol. 22, no 1, 75-79 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-112434DOI: 10.1093/jac/22.1.75PubMedID: 3170393OAI: diva2:777371
Available from: 2015-01-08 Created: 2014-11-26 Last updated: 2015-01-19Bibliographically approved

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Maller, RolfIsaksson, Barbro
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