Applications of self-assembling peptide scaffolds in regenerative medicine: the way to the clinic
2014 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 2, no 48, 8466-8478 p.Article in journal (Refereed) Published
Peptides that self-assemble into well-defined nanofibrous networks provide a prominent alternative to traditional biomaterials for fabricating scaffolds for use in regenerative medicine and other biomedical applications. Such scaffolds can be generated by decorating a peptide backbone with other bioactives such as cell specific adhesion peptides, growth factors and enzyme cleavable sequences. They can be designed to mimic the three-dimensional (3D) structural features of native ECM and can therefore also provide insight into the ECM-cell interactions needed for development of scaffolds that can serve as regeneration templates for specific target tissues or organs. This review highlights the potential application of self-assembling peptides in regenerative medicine.
Place, publisher, year, edition, pages
Royal Society of Chemistry , 2014. Vol. 2, no 48, 8466-8478 p.
Physical Sciences Clinical Medicine
IdentifiersURN: urn:nbn:se:liu:diva-113073DOI: 10.1039/c4tb01095gISI: 000345529400002OAI: oai:DiVA.org:liu-113073DiVA: diva2:778235
Funding Agencies|Swedish Research Council, Sweden [2012-42315-94008-81]2015-01-092015-01-082015-01-21