The cerebrospinal fluid "Alzheimer profile": Easily said, but what does it mean?
2014 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 10, no 6, 713-723 p.Article in journal (Refereed) Published
Background: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-beta(1-42) (A beta(42)), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimers disease (AD). Methods: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/A beta(42) ratio and 0.08 for the p-tau/A beta(42) ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/A beta(42) ratio. Conclusions: A tau/A beta(42) ratio of greater than0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.
Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 10, no 6, 713-723 p.
Dementia; Alzheimers disease; Mild cognitive impairment; Cerebrospinal fluid; Amyloid-beta(1-42); Tau; Biomarkers; Differential diagnosis; Predictive value
IdentifiersURN: urn:nbn:se:liu:diva-113059DOI: 10.1016/j.jalz.2013.12.023ISI: 000345310800016PubMedID: 24721526OAI: oai:DiVA.org:liu-113059DiVA: diva2:778286
Funding Agencies|Alzheimer Nederland fund; Stichting VUMC fund; Stichting Dioraphte2015-01-092015-01-082015-01-09