liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The cerebrospinal fluid "Alzheimer profile": Easily said, but what does it mean?
Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands.
Vrije University of Amsterdam, Netherlands.
Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands.
Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands; University of Maastricht, Netherlands.
Show others and affiliations
2014 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 10, no 6, 713-723 p.Article in journal (Refereed) Published
Abstract [en]

Background: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-beta(1-42) (A beta(42)), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimers disease (AD). Methods: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/A beta(42) ratio and 0.08 for the p-tau/A beta(42) ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/A beta(42) ratio. Conclusions: A tau/A beta(42) ratio of greater than0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 10, no 6, 713-723 p.
Keyword [en]
Dementia; Alzheimers disease; Mild cognitive impairment; Cerebrospinal fluid; Amyloid-beta(1-42); Tau; Biomarkers; Differential diagnosis; Predictive value
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-113059DOI: 10.1016/j.jalz.2013.12.023ISI: 000345310800016PubMedID: 24721526OAI: oai:DiVA.org:liu-113059DiVA: diva2:778286
Note

Funding Agencies|Alzheimer Nederland fund; Stichting VUMC fund; Stichting Dioraphte

Available from: 2015-01-09 Created: 2015-01-08 Last updated: 2017-12-05

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Marcusson, Jan

Search in DiVA

By author/editor
Marcusson, Jan
By organisation
Division of NeuroscienceFaculty of Health SciencesDepartment of Geriatric Medicine in Linköping
In the same journal
Alzheimer's & Dementia
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 100 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf