Delayed HIV diagnosis common in Sweden, 2003-2010
2014 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 46, no 12, 862-867 p.Article in journal (Refereed) Published
Background: Early diagnosis of HIV is important for the prognosis of individual patients, because antiretroviral treatment can be started at the appropriate time, and for public health, because transmission can be prevented. Methods: Data were collected from 767 HIV patients who were diagnosed in Sweden during 2003-2010 and were infected in Sweden or born in Sweden and infected abroad. A recent infection testing algorithm (RITA) was applied to BED-EIA test results (OD-n less than 0.8), CD4 counts (greater than= 200 cells/mu l), and clinical information. A recent infection classification was used as indicator for early diagnosis. Time trends in early diagnosis were investigated to detect population changes in HIV testing behavior. Patients with early diagnosis were compared to patients with delayed diagnosis with respect to age, gender, transmission route, and country of infection (Sweden or abroad). Results: Early diagnosis was observed in 271 patients (35%). There was no statistically significant time trend in the yearly percentage of patients with early diagnosis in the entire study group (p = 0.836) or in subgroups. Early diagnosis was significantly more common in men who have sex men (MSM) (45%) than in heterosexuals (21%) and injecting drug users (27%) (p less than 0.001 and p = 0.001, respectively) in both univariate and multivariable analyses. The only other factor that remained associated with early diagnosis in multivariable analysis was young age group. Conclusion: Approximately one-third of the study patients were diagnosed early with no significant change over time. Delayed HIV diagnosis is a considerable problem in Sweden, which does not appear to diminish.
Place, publisher, year, edition, pages
Informa Healthcare , 2014. Vol. 46, no 12, 862-867 p.
HIV; delayed diagnosis; immunoassay; trends; risk factors
Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:liu:diva-113007DOI: 10.3109/00365548.2014.953575ISI: 000345238100008PubMedID: 25290584OAI: oai:DiVA.org:liu-113007DiVA: diva2:779067
Funding Agencies|Swedish Research Council [K2008-56X-09935-17-3, K2001-35 56X-0095-20-6, 623-2011-1100, 623-2013-8905]; Swedish International Development Cooperation Agency [SWE-2006-018]; EU project: SPREAD [QLK2-CT-2001-37 01344]; EU project: EHR [LSHP-CT-2006-518211]; EU project: CHAIN; Collaborative HIV and Anti-HIV Drug Resistance Network [223131, 260694]2015-01-122015-01-082015-01-12