DNA Translocations through Solid-State Plasmonic Nanopores
2014 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 14, no 12, 6917-6925 p.Article in journal (Refereed) Published
Nanopores enable label-free detection and analysis of single biomolecules. Here, we investigate DNA translocations through a novel type of plasmonic nanopore based on a gold bowtie nanoantenna with a solid-state nanopore at the plasmonic hot spot. Plasmonic excitation of the nanopore is found to influence both the sensor signal (nanopore ionic conductance blockade during DNA translocation) and the process that captures DNA into the nanopore, without affecting the duration time of the translocations. Most striking is a strong plasmon-induced enhancement of the rate of DNA translocation events in lithium chloride (LiCl, already 10-fold enhancement at a few mW of laser power). This provides a means to utilize the excellent spatiotemporal resolution of DNA interrogations with nanopores in LiCl buffers, which is known to suffer from low event rates. We propose a mechanism based on plasmon-induced local heating and thermophoresis as explanation of our observations.
Place, publisher, year, edition, pages
American Chemical Society , 2014. Vol. 14, no 12, 6917-6925 p.
Nanopores; plasmonics; thermophoresis; single-molecule sensing; biosensing; DNA
IdentifiersURN: urn:nbn:se:liu:diva-113372DOI: 10.1021/nl503034jISI: 000346322800026PubMedID: 25347403OAI: oai:DiVA.org:liu-113372DiVA: diva2:781558
Funding Agencies|National Human Genome Research Institute of the National Institute of Health [1R01HG007406-01]; Wenner-Gren Fellowship from the Wenner-Gren Foundations; ERC Advanced grant (NanoforBio) ; Netherlands Organization for Scientific Research (NWO/OCW), as part of the Frontiers of Nanoscience program2015-01-162015-01-162015-06-04