liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The impact of tumour angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival in squamous cervical carcinoma.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Department of Gynecologic Oncology Epidemiology and Biostatistics, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.
Department of Tumour Pathology Epidemiology and Biostatistics, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.
Department of Tumour Pathology Epidemiology and Biostatistics, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.
Department of Cancer Epidemiology and Biostatistics, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.
Show others and affiliations
1997 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 33, no 11, 1799-1804 p.Article in journal (Refereed) Published
Abstract [en]

Tumour angiogenesis (antifactor VIII-related antigen antibody), p53 overexpression (DO-1) and proliferative activity (MIB-1) were immunohistochemically analysed for the prediction of long-term survival in 113 patients with squamous cervical carcinoma. The median follow-up time was 82 months (range 72-99). In early stages (IB-IIA), neovascularisation was significantly related to tumour size. Significantly more patients in stage IIA had high tumour vascularity compared to stage IB (P < 0.01) but no significant difference was found between early and advanced stages (IIB-IVB) of cervical carcinoma. p53 overexpression was correlated to the stage of disease (P < 0.01). No relationship was found between tumour angiogenesis, p53 overexpression or MIB-1 and pelvic lymph node metastases, histological subtype or differentiation. Tumours with more than 50% p53 overexpression was significantly correlated with survival in the univariate analysis, but no independent predictive value was found. It is concluded that immunohistochemically detectable p53 overexpression as measured by DO-1 and proliferative activity as measured by MIB-1 seems of no clinical value for the prediction of long-term survival in squamous cervical carcinoma. The predictive value of tumour angiogenesis for survival outcome has still to be determined in squamous cervical carcinoma.

Place, publisher, year, edition, pages
1997. Vol. 33, no 11, 1799-1804 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-113906DOI: 10.1016/S0959-8049(97)00161-5PubMedID: 9470836OAI: oai:DiVA.org:liu-113906DiVA: diva2:785634
Available from: 2015-02-03 Created: 2015-02-03 Last updated: 2017-12-05

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Åvall-Lundqvist, Elisabeth

Search in DiVA

By author/editor
Åvall-Lundqvist, Elisabeth
By organisation
Division of Clinical SciencesFaculty of Health Sciences
In the same journal
European Journal of Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 79 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf