Ca2+ transport in isolated mouse liver mitochondria; role of reductive carboxylation and citrate?
1986 (English)In: Cell Calcium, ISSN 0143-4160, E-ISSN 1532-1991, Vol. 7, no 4, 275-282 p.Article in journal (Refereed) Published
The uptake of Ca2+ in isolated mouse liver mitochondria respiring on succinate in the presence of rotenone and added Pi, was inhibited by dibucaine, fluorocitrate, p-hydroxymercuribenzoate (PMB), malonate, palmitoyl-CoA, succinyl-CoA and trifluoroperazine. The release of accumulated Ca2+ was stimulated by arsenite, malonate, PMB, palmitoyl-CoA and succinyl-CoA, whereas the release was inhibited by dibucaine, fluorocitrate, trifluoroperazine, and by oligomycin, especially in the presence of ADP. The pyridine nucleotides were oxidized in mitochondria incubated with PMB. The observations suggest a possible contributory role of reductive carboxylation for the uptake of Ca2+, and a possible role of citrate for the retention of Ca2+ in isolated mouse liver mitochondria.
Place, publisher, year, edition, pages
Elsevier, 1986. Vol. 7, no 4, 275-282 p.
IdentifiersURN: urn:nbn:se:liu:diva-113927DOI: 10.1016/0143-4160(86)90006-0PubMedID: 3768942OAI: oai:DiVA.org:liu-113927DiVA: diva2:785647