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Laminin-5 gamma2 chain expression facilitates detection of invasive squamous cell carcinoma of the uterine cervix.
Division of Cellular and Molecular Tumor Pathology, Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden.
Department of Biochemistry, University of Oulu, Finland.
Division of Cellular and Molecular Tumor Pathology, Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden.
Division of Cellular and Molecular Tumor Pathology, Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden.
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2004 (English)In: International Journal of Gynecological Pathology, ISSN 0277-1691, E-ISSN 1538-7151, Vol. 23, no 3, 215-222 p.Article in journal (Refereed) Published
Abstract [en]

Because it has been suggested that laminin-5 can be used as a sensitive marker for epithelial cell invasion, specimens from patients with invasive squamous cell carcinoma of the uterine cervix with a previous history of preinvasive lesions were evaluated by a newly developed monoclonal antibody directed against the gamma2 chain of laminin-5. Thirty-two archival paraffin specimens consisting of the matched preinvasive and invasive lesions from 15 women were evaluated to determine whether gamma2 chain laminin-5 staining was present in lesions that progressed to invasive cancer. With the exception of one tumor (a small cell nonkeratinizing squamous carcinoma), all squamous cell carcinomas exhibited positive staining. Five of 17 preinvasive lesions also were immunoreactive for the laminin-5 protein. A blinded histologic reevaluation revealed invasion or lesions suspicious for invasion in four of five preinvasive lesions. Our findings suggest that laminin-5 determined by a monoclonal antibody facilitates the identification of invasive lesions that are difficult or impossible to identify on routinely stained histologic sections.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2004. Vol. 23, no 3, 215-222 p.
Keyword [en]
Laminin-5 γ2, Squamous cell carcinoma, Uterine cervix
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:liu:diva-113936DOI: 10.1097/01.pgp.0000130107.95607.f6ISI: 000222324200003PubMedID: 15213597Scopus ID: 2-s2.0-3042804847OAI: oai:DiVA.org:liu-113936DiVA: diva2:785721
Available from: 2015-02-03 Created: 2015-02-03 Last updated: 2017-04-20Bibliographically approved

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Åvall-Lundqvist, Elisabeth

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