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A population-based study of cervical carcinoma and HPV infection in Latvia.
Oncology Center of Latvia, Riga, Latvia / Department of Gynecologic Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden / Department of Medical Microbiology, MAS University Hospital, Malmö, Sweden.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology. Department of Medical Microbiology, MAS University Hospital, Malmö, Sweden.
Merck Research Laboratories, West Point, PA 19486, USA.
Merck Research Laboratories, West Point, PA 19486, USA.
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2004 (English)In: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 93, no 2, 484-492 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: We wished to quantify the population-based importance of cervical carcinoma risk factors in Latvia.

METHODS: Totally, 223 of 224 eligible cases of incident invasive cervical carcinoma were enrolled during July 1998-February 2001 in Latvia. An age-matched sample of 300 healthy control women was selected from the Latvian population registry and 239 of these women (79%) were enrolled. A demographic and life-style questionnaire was completed, cervical brush samples were analyzed for human papillomavirus (HPV) DNA by PCR and serum samples for HPV antibodies.

RESULTS: Risk factors for cervical cancer in multivariate analysis were HPV type 16 or 18 DNA positivity (OR = 32.4; CI 95% 16.5-63.6) and living in the capital (OR = 2.4; CI 95% 1.2-4.7). Oral contraceptive use was not a risk factor (OR = 0.4; CI 95% 0.2-1.1). A strong protective effect was found for having had more than three Pap smears in the last 5 years (OR = 0.07 CI 95% 0.03-0.19).

CONCLUSIONS: Inadequate population coverage of Pap smears, in spite of excessive smear usage, caused 28.4% of cervical cancers in age groups eligible for screening. HPV type 16 infection was the most important risk factor for cervical cancer in Latvia, with a population-attributable risk percent for all ages of 58.5%.

Place, publisher, year, edition, pages
2004. Vol. 93, no 2, 484-492 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-113935DOI: 10.1016/j.ygyno.2004.01.044PubMedID: 15099967OAI: diva2:785727
Available from: 2015-02-03 Created: 2015-02-03 Last updated: 2015-02-13

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Wang, XiaodongÅvall-Lundqvist, Elisabeth
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