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Dehydration, hemodynamics and fluid volume optimization after induction of general anesthesia
Shaoxing Peoples Hospital, Peoples R China; Zhejiang University, Peoples R China.
Shaoxing Peoples Hospital, Peoples R China.
Shaoxing Peoples Hospital, Peoples R China.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping. Sodertalje Hospital, Sweden.
2014 (English)In: Clinics, ISSN 1807-5932, E-ISSN 1980-5322, Vol. 69, no 12, 809-816 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Fluid volume optimization guided by stroke volume measurements reduces complications of colorectal and high-risk surgeries. We studied whether dehydration or a strong hemodynamic response to general anesthesia increases the probability of fluid responsiveness before surgery begins. METHODS: Cardiac output, stroke volume, central venous pressure and arterial pressures were measured in 111 patients before general anesthesia (baseline), after induction and stepwise after three bolus infusions of 3 ml/kg of 6% hydroxyethyl starch 130/0.4 (n = 86) or Ringers lactate (n = 25). A subgroup of 30 patients who received starch were preloaded with 500 ml of Ringers lactate. Blood volume changes were estimated from the hemoglobin concentration and dehydration was estimated from evidence of renal water conservation in urine samples. RESULTS: Induction of anesthesia decreased the stroke volume to 62% of baseline (mean); administration of fluids restored this value to 84% (starch) and 68% (Ringers). The optimized stroke volume index was clustered around 35-40 ml/m(2)/beat. Additional fluid boluses increased the stroke volume by greater than= 10% (a sign of fluid responsiveness) in patients with dehydration, as suggested by a low cardiac index and central venous pressure at baseline and by high urinary osmolality, creatinine concentration and specific gravity. Preloading and the hemodynamic response to induction did not correlate with fluid responsiveness. The blood volume expanded 2.3 (starch) and 1.8 (Ringers) times over the infused volume. CONCLUSIONS: Fluid volume optimization did not induce a hyperkinetic state but ameliorated the decrease in stroke volume caused by anesthesia. Dehydration, but not the hemodynamic response to the induction, was correlated with fluid responsiveness.

Place, publisher, year, edition, pages
Faculdade de Medicina / USP , 2014. Vol. 69, no 12, 809-816 p.
Keyword [en]
Fluid Therapy; Central Hemodynamics; Dehydration; General Anesthesia
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-114266DOI: 10.6061/clinics/2014(12)04ISI: 000348215800004OAI: diva2:788579

Funding Agencies|Qianjiang Talents Project of the Technology Office in Zhejiang province, PR China [2012R10033]; Ostergotland City Council, Sweden [LiO-297751]

Available from: 2015-02-16 Created: 2015-02-16 Last updated: 2015-02-16

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Hahn, Robert
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Division of Drug ResearchFaculty of Health SciencesDepartment of Anaesthesiology and Intensive Care in Linköping
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