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Porous titania surfaces on titanium with hierarchical macro- and mesoporosities for enhancing cell adhesion, proliferation and mineralization
Stockholm University, Sweden.
Johannes Gutenberg University of Mainz, Germany.
Johannes Gutenberg University of Mainz, Germany.
Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, The Institute of Technology. Stockholm University, Sweden.
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2015 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 47, 376-383 p.Article in journal (Refereed) Published
Abstract [en]

Titanium received a macroporous titania surface layer by anodization, which contains open pores with average pore diameter around 5 gm. An additional mesoporous titania top layer following the contour of the macropores, of 100-200 nm thickness and with a pore diameter of 10 nm, was formed by using the evaporation-induced self-assembly (EISA) method with titanium (IV) tetraethoxide as the precursor. A coherent laminar titania surface layer was thus obtained, creating a hierarchical macro- and mesoporous surface that was characterized by high-resolution electron microscopy. The interfacial bonding between the surface layers and the titanium matrix was characterized by the scratch test that confirmed a stable and strong bonding of titania surface layers on titanium. The wettability to water and the effects on the osteosarcoma cell line (SaOS-2) proliferation and mineralization of the formed titania surface layers were studied systematically by cell culture and scanning electron microscopy. The results proved that the porous titania surface with hierarchical macro- and mesoporosities was hydrophilic that significantly promoted cell attachment and spreading. A synergistic role of the hierarchical macro- and mesoporosities was revealed in terms of enhancing cell adhesion, proliferation and mineralization, compared with the titania surface with solo scale topography.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 47, 376-383 p.
Keyword [en]
Porosity; Titanium oxide; Cell adhesion; Cell proliferation; Surface topography
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-114233DOI: 10.1016/j.msec.2014.11.021ISI: 000347581600045PubMedID: 25492210OAI: oai:DiVA.org:liu-114233DiVA: diva2:788748
Note

Funding Agencies|European Commission [604036, 215507, 286059, 266033, 268476, 311848]; Knut and Alice Wallenberg foundation; ERC Advanced Investigator Grant [268476]; Deutsche Forschungsgemeinschaft [Schr 277/10-2]; International Human Frontier Science Program; Public Welfare Project of Ministry of Land and Resources of the Peoples Republic of China [201011005-06]; International Science and Technology Cooperation Program of China [2008DFA00980]

Available from: 2015-02-16 Created: 2015-02-16 Last updated: 2017-12-04

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Lilja, Louise

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