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Photodiagnostics in Brain Tumor Surgery
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Medicine and Health Sciences. (MINT)ORCID iD: 0000-0002-0555-8877
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Medicine and Health Sciences. (MINT)
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
2014 (English)In: Medicinteknikdagarna, Göteborg, 14-16 oktober, 2014: Sammanfattningar, Göteborg: Svensk förening för medicinsk teknik och fysik , 2014Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Since getting approved for clinical application in neurosurgery 5-aminolevulinic acid (ALA), that is a fluorescence contrast agent, has attracted the interest of many neurosurgical clinics to implement it in their surgical routine. ALA naturally exists in the body and the external administration of the substance induces accumulation of a fluorophore known as protoporphyrin IX (PpIX) in the malignant cells due to a broken blood brain barrier and the altered enzyme levels in the brain tumor. The detection and visualization of PpIX in the clinical routine is conventionally performed using a modified neuro surgical microscope. As a complementary technique for detection of ALA-induced fluorescence and to perform objective and quantitative measurements, our group has developed a spectroscopy system adapted to the equipment in the operating room. The system includes a hand-held fiber optic probe which can be integrated in the neuronavigation and stereotactic systems. The main advantages of the system are the ease of use, high sensitivity, quantitative fluorescence detection and the possibility of applying a low dose of fluorescence contrast agent while obtaining equally reliable results as with the high dose. In this contribution we present our experience, gains and challenges from implementation of the system during brain tumor surgery in forty adult patients. The methods and systems are currently being adapted for implementation during operations of pediatric brain tumors.

Place, publisher, year, edition, pages
Göteborg: Svensk förening för medicinsk teknik och fysik , 2014.
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-114296OAI: oai:DiVA.org:liu-114296DiVA: diva2:789000
Conference
Medicinteknikdagarna, Göteborg, 14-16 oktober, 2014
Available from: 2015-02-17 Created: 2015-02-17 Last updated: 2017-02-13Bibliographically approved

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Haj-Hosseini, NedaRichter, JohanWårdell, Karin

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