liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Whole Body Mechanistic Minimal Model for Gd-EOB-DTPA Contrast Agent Pharmacokinetics in Evaluation of Diffuse Liver Disease
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-4630-6550
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0002-4111-1693
Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology. Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Show others and affiliations
2014 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Purpose: Aiming for non-invasive diagnostic tools to decrease the need for biopsy in diffuse liver disease and to quantitatively describe liver function, we applied a mechanistic pharmacokinetic modelling analysis of liver MRI with Gd-EOB-DTPA. This modelling method yields physiologically relevant parameters and was compared to previously developed methods in a patient group with diffuse liver disease. Materials and Methods: Using data from healthy volunteers undergoing liver MRI, an identifiable mechanistic model was developed, based on compartments described by ordinary differential equations and kinetic expressions, and validated with independent data including Gd-EOB-DTPA concentration measurements in blood samples. Patients (n=37) with diffuse liver disease underwent liver biopsy and MRI with Gd-EOB-DTPA. The model was used to derive pharmacokinetic parameters which were then compared with other quantitative estimates in their ability to separate mild from severe liver fibrosis. Results: The estimations produced by the mechanistic model allowed better separation between mild and severe fibrosis than previously described methods for quantifying hepatic Gd-EOB-DTPA uptake. Conclusions: With a mechanistic pharmacokinetic modelling approach, the estimation of liver uptake function and its diagnostic information can be improved compared to current methods.

Place, publisher, year, edition, pages
2014.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-114363OAI: oai:DiVA.org:liu-114363DiVA: diva2:789533
Conference
Society of Abdominal Radiology (SAR) 2014 Boca Raton, Florida, USA
Available from: 2015-02-19 Created: 2015-02-19 Last updated: 2015-06-12

Open Access in DiVA

No full text

Other links

http://www.researchgate.net/publication/264372183_Whole_Body_Mechanistic_Minimal_Model_for_Gd-EOB-DTPA_Contrast_Agent_Pharmacokinetics_in_Evaluation_of_Diffuse_Liver_Disease

Authority records BETA

Forsgren, MikaelDahlström, NilsKarlsson, MarkusDahlqvist Leinhard, OlofSmedby, ÖrjanCedersund, GunnarLundberg, Peter

Search in DiVA

By author/editor
Forsgren, MikaelDahlström, NilsKarlsson, MarkusDahlqvist Leinhard, OlofSmedby, ÖrjanCedersund, GunnarLundberg, Peter
By organisation
Division of Radiological SciencesFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Radiation PhysicsDepartment of Radiology in LinköpingSoftware and SystemsThe Institute of TechnologyDivision of NeuroscienceDepartment of Biomedical Engineering
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 226 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf