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Quantitative Assessment of Turbulence and Flow Eccentricity in an Aortic Coarctation - Impact of Virtual Interventions
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-4656-7662
Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-1942-7699
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.ORCID iD: 0000-0003-1395-8296
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-5526-2399
2015 (English)In: Cardiovascular Engineering and Technology, ISSN 1869-408X, E-ISSN 1869-4098, Vol. 6, no 6, 281-293 p.Article in journal (Refereed) Published
Abstract [en]

Turbulence and flow eccentricity can be measured by magnetic resonance imaging (MRI) and may play an important role in the pathogenesis of numerous cardiovascular diseases. In the present study, we propose quantitative techniques to assess turbulent kinetic energy (TKE) and flow eccentricity that could assist in the evaluation and treatment of stenotic severities. These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. Patient-specific geometry and flow conditions were derived from MRI data. The unsteady pulsatile flow was resolved by large eddy simulation (LES) including non-Newtonian blood rheology. Results showed an inverse asymptotic relationship between the total amount of TKE and degree of dilatation of the stenosis, where turbulent flow proximal the constriction limits the possible improvement by treating the CoA alone. Spatiotemporal maps of TKE and flow eccentricity could be linked to the characteristics of the jet, where improved flow conditions were favored by an eccentric dilatation of the CoA. By including these flow markers into a combined MRI-CFD intervention framework, CoA therapy has not only the possibility to produce predictions via simulation, but can also be validated pre- and immediate post treatment, as well as during follow-up studies.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 6, no 6, 281-293 p.
Keyword [en]
Computational fluid dynamics, Large eddy simulation, Turbulent kinetic energy, Flow displacement, Non-Newtonian, Virtual treatment, Magnetic resonance imaging
National Category
Applied Mechanics
Identifiers
URN: urn:nbn:se:liu:diva-114496DOI: 10.1007/s13239-015-0218-xISI: 000380356800007OAI: oai:DiVA.org:liu-114496DiVA: diva2:790422
Note

Funding agencies: Swedish Research Council; Center for Industrial Information Technology (CENIIT); Swedish National Infrastructure for Computing (SNIC)

Available from: 2015-02-24 Created: 2015-02-24 Last updated: 2017-12-04Bibliographically approved

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Andersson, MagnusLantz, JonasEbbers, TinoKarlsson, Matts

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Applied Thermodynamics and Fluid MechanicsThe Institute of TechnologyMedia and Information TechnologyDivision of Cardiovascular MedicineFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in Linköping
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Cardiovascular Engineering and Technology
Applied Mechanics

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