Mechanistic Modelling Investigates the Neural Basis behind the Hemodynamic Response in fMRI
2015 (English)In: 16TH NORDIC-BALTIC CONFERENCE ON BIOMEDICAL ENGINEERING, Springer Science Business Media , 2015, Vol. 48, 86-87 p.Conference paper (Refereed)
This work serves as a basis for a new type of fMRI analysis, which is based on a mechanistic interpretation of the hemodynamic response to synaptic activity. Activation was measured in the visual cortex of 12 healthy controls and ordinary differential equation models were fitted to the time series of the hemodynamic response. This allowed us to reject or refine previously proposed mechanistic hypotheses. This is the first attempt to describe the hemodynamic response quantitatively based on recent neurobiological findings. This mechanistic approach stands in contrast to the standard phenomenological description using the gamma variate function.
Place, publisher, year, edition, pages
Springer Science Business Media , 2015. Vol. 48, 86-87 p.
, IFMBE Proceedings, ISSN 1680-0737 ; 48
functional magnetic resonance imaging (fMRI); blood oxygen level dependent (BOLD) response; mechanistic modeling; ordinary differential equations (ODE); neurovascular coupling
IdentifiersURN: urn:nbn:se:liu:diva-114431DOI: 10.1007/978-3-319-12967-9_23ISI: 000347893000023ISBN: 978-3-319-12966-2OAI: oai:DiVA.org:liu-114431DiVA: diva2:791939
16th Nordic-Baltic Conference on Biomedical Engineering (NBC) / 10th MTD Joint Conference