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Mechanistic Modelling Investigates the Neural Basis behind the Hemodynamic Response in fMRI
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-2167-2450
2015 (English)In: 16TH NORDIC-BALTIC CONFERENCE ON BIOMEDICAL ENGINEERING, Springer Science Business Media , 2015, Vol. 48, 86-87 p.Conference paper, Published paper (Refereed)
Abstract [en]

This work serves as a basis for a new type of fMRI analysis, which is based on a mechanistic interpretation of the hemodynamic response to synaptic activity. Activation was measured in the visual cortex of 12 healthy controls and ordinary differential equation models were fitted to the time series of the hemodynamic response. This allowed us to reject or refine previously proposed mechanistic hypotheses. This is the first attempt to describe the hemodynamic response quantitatively based on recent neurobiological findings. This mechanistic approach stands in contrast to the standard phenomenological description using the gamma variate function.

Place, publisher, year, edition, pages
Springer Science Business Media , 2015. Vol. 48, 86-87 p.
Series
IFMBE Proceedings, ISSN 1680-0737 ; 48
Keyword [en]
functional magnetic resonance imaging (fMRI); blood oxygen level dependent (BOLD) response; mechanistic modeling; ordinary differential equations (ODE); neurovascular coupling
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-114431DOI: 10.1007/978-3-319-12967-9_23ISI: 000347893000023ISBN: 978-3-319-12966-2 (print)OAI: oai:DiVA.org:liu-114431DiVA: diva2:791939
Conference
16th Nordic-Baltic Conference on Biomedical Engineering (NBC) / 10th MTD Joint Conference
Available from: 2015-03-02 Created: 2015-02-20 Last updated: 2016-04-14

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Lundengård, KarinCedersund, GunnarElinder, FredrikEngström, Maria

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Lundengård, KarinCedersund, GunnarElinder, FredrikEngström, Maria
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Division of Radiological SciencesFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Biomedical EngineeringFaculty of Science & EngineeringDivision of Cell BiologyFaculty of Medicine and Health Sciences
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Citation style
  • apa
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