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Mammography and Osteoporosis Screening-Clinical Risk Factors and Their Association With Digital X-Ray Radiogrammetry Bone Mineral Density
Karolinska University Hospital, Sweden.
Skåne University Hospital, Sweden.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Sectra AB, Linkoping, Sweden.ORCID iD: 0000-0002-3486-796X
Sectra AB, Linkoping, Sweden.
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2015 (English)In: Journal of clinical densitometry, ISSN 1094-6950, Vol. 18, no 1, 22-29 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univariate associations between DXR T-score and risk factors were examined. A generalized linear regression model was fitted to independent variables with univariate associations at p less than 0.05. The multivariable model was reduced through manual backward elimination, with p greater than 0.1 as the exclusion criterion. Seventy-six percent of the women chose to participate in the study (n = 8810). The difference in number of daily mammograms performed on study vs nonstudy days was not significant. All univariate associations between DXR T-score and potential risk factors were highly significant. The multivariable model included height, weight, age, right-handedness, menopause before age 45, alcohol consumption, cortisone treatment, rheumatic disease, and age x smoking status. The coefficient of determination of the model was 0.37. The association between risk factors for osteoporosis and DXR T-score is similar to previously reported associations with dual-energy X-ray absorptiometry.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 18, no 1, 22-29 p.
Keyword [en]
Bone mineral density; digital X-ray radiogrammetry; mammography; osteoporosis; screening
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-115003DOI: 10.1016/j.jocd.2014.07.007ISI: 000348970300006PubMedID: 25294740OAI: diva2:793747

Funding Agencies|Stockholm County Council; Karolinska Institutet

Available from: 2015-03-09 Created: 2015-03-06 Last updated: 2015-03-19

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Kälvesten, Johan
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