An Optical Method for Serum Calcium and Phosphorus Level Assessment during Hemodialysis
2015 (English)In: Toxins, ISSN 2072-6651, Vol. 7, no 3, 719-727 p.Article in journal (Refereed) Published
Survival among hemodialysis patients is disturbingly low, partly because vascular calcification (VC) and cardiovascular disease are highly prevalent. Elevated serum phosphorus (P) and calcium (Ca) levels play an essential role in the formation of VC events. The purpose of the current study was to reveal optical monitoring possibilities of serum P and Ca values during dialysis. Twenty-eight patients from Tallinn (Estonia) and Linköping (Sweden) were included in the study. The serum levels of Ca and P on the basis of optical information, i.e., absorbance and fluorescence of the spent dialysate (optical method) were assessed. Obtained levels were compared in means and SD. The mean serum level of Ca was 2.54 ± 0.21 and 2.53 ± 0.19 mmol/L; P levels varied between 1.08 ± 0.51 and 1.08 ± 0.48 mmol/L, measured in the laboratory and estimated by the optical method respectively. The levels achieved were not significantly different (p = 0.5). The Bland-Altman 95% limits of agreement between the two methods varied from -0.19 to 0.19 for Ca and from -0.37 to 0.37 in the case of P. In conclusion, optical monitoring of the spent dialysate for assessing the serum levels of Ca and P during dialysis seems to be feasible and could offer valuable and continuous information to medical staff.
Place, publisher, year, edition, pages
BASEL, SWITZERLAND, 2015. Vol. 7, no 3, 719-727 p.
Health Care Service and Management, Health Policy and Services and Health Economy
IdentifiersURN: urn:nbn:se:liu:diva-115147DOI: 10.3390/toxins7030719ISI: 000359339500006PubMedID: 25734785OAI: oai:DiVA.org:liu-115147DiVA: diva2:793999
The research was funded partly by the County Council of Ostergotland, Sweden, Estonian Science Foundation Grant No. 8621, Estonian Ministry of Education and Research under institutional research financing IUT 19-2 and the European Union through the European Regional Development Fund.2015-03-102015-03-102016-03-23