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Do Depressive Symptoms Mediate the Relationship Between Hopelessness and Diurnal Cortisol Rhythm?
University of Louisville.
University of Louisville.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.
2015 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 22, no 2, 251-257 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Research has revealed a well-established relationship of depressive symptoms and hopelessness with a variety of physical illnesses that are associated with a dysfunction of the hypothalamic-pituitary-adrenal-axis.

PURPOSE: The purpose of this study was to test if depressive symptoms mediate the relationship between hopelessness and cortisol, a measure of the hypothalamic-pituitary-adrenal-axis.

METHODS: Hopelessness, depressive symptoms, and diurnal cortisol rhythm were measured in 257 adults (128 women and 129 men; age range, 20-74 years) in this cross-sectional study. To test the hypothesis, two linear regression analyses and asymmetrical confidence intervals around the regression weights were conducted. A second set of analyses was calculated to be able to exclude the possibility of hopelessness as a mediator between depressive symptoms and cortisol.

RESULTS: As predicted, after adjusting for age, gender, awakening time, and medication use, more hopelessness predicted more depressive symptoms and more depressive symptoms predicted a flatter diurnal cortisol rhythm. The 95 % confidence intervals revealed that the indirect relationship between hopelessness and diurnal cortisol rhythm was significant. The analyses with hopelessness as a potential mediator revealed that hopelessness does not mediate the association between depressive symptoms and cortisol.

CONCLUSIONS: While the relationship between hopelessness and cortisol was mediated by depressive symptoms in this cross-sectional study, many other risk factors of depression have not been examined. Thus, future longitudinal studies should examine the relationships between those risk factors of depression and the hypothalamic-pituitary-adrenal-axis.

Place, publisher, year, edition, pages
2015. Vol. 22, no 2, 251-257 p.
Keyword [en]
Population-based Cross-sectional study Mediation model Hopelessness Depressive symptoms Diurnal cortisol rhythm
National Category
Other Medical Sciences not elsewhere specified
Identifiers
URN: urn:nbn:se:liu:diva-115573DOI: 10.1007/s12529-014-9422-6ISI: 000351523600011PubMedID: 25475609OAI: oai:DiVA.org:liu-115573DiVA: diva2:796125
Available from: 2015-03-18 Created: 2015-03-17 Last updated: 2017-12-04

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Sjögren, ElaineKristenson, Margareta

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