liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Left ventricular diastolic function, assessed by echocardiography and tissue Doppler imaging, is a strong predictor of cardiovascular events, superior to global left ventricular longitudinal strain, in patients with type 2 diabetes.
County Hospital Ryhov, Jönköping, Sweden.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Endocrinology.
Show others and affiliations
2015 (English)In: European heart journal cardiovascular Imaging, ISSN 2047-2412, Vol. 16, no 9, 1000-1007 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: The aim of the study was to determine whether left ventricular systolic function, in terms of global left ventricular longitudinal strain (GLS), and diastolic function, expressed as the ratio between early diastolic transmitral flow and mitral annular motion velocities (E/e'), can predict cardiovascular events in patients with diabetes mellitus type 2.

METHODS AND RESULTS: We prospectively investigated 406 consecutive patients, aged 55-65 years, with diabetes mellitus, who participated in the CARDIPP study. Echocardiography, pulse pressure (pp), and glycosylated haemoglobin (HbA1c) were analysed. Twelve cases of myocardial infarction and seven cases of stroke were identified during the follow-up period of 67 ± 17 months. Univariate Cox regression analysis showed that E/e' was a strong predictor of cardiovascular events (hazards ratio 1.12; 95% confidence interval 1.06-1.18, P < 0.001). E/e' was prospectively associated with cardiovascular events independent of age, sex, GLS, left ventricular ejection fraction (LVEF), pp, and HbA1c in multivariate analysis. Receiver operating characteristic curves showed that E/e' and HbA1c were the strongest predictors for cardiovascular events, both having an area under the curve (AUC) of 0.71 followed by LVEF with an AUC of 0.65 and GLS of 0.61. In a Kaplan-Meyer analysis, the cumulative probability of an event during the follow-up period was 8.6% for patients with an E/e' ratio >15 compared with 2.6% for patients with E/e' ≤15, P = 0.011.

CONCLUSION: In middle-aged patients with type 2 diabetes, E/e' is a strong predictor of myocardial infarction and stroke, comparable with HbA1c and superior to GLS and LVEF.

Place, publisher, year, edition, pages
Oxford University Press, 2015. Vol. 16, no 9, 1000-1007 p.
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-115748DOI: 10.1093/ehjci/jev027ISI: 000364539700011PubMedID: 25750201OAI: oai:DiVA.org:liu-115748DiVA: diva2:796248
Note

Funding agencies: FORSS; Research Council of Southeastern Sweden; King Gustaf V and Queen Victoria Freemason Foundation, Sweden; Linkoping University; Futurum-the Academy for Healthcare, Jonkoping County Council

Available from: 2015-03-18 Created: 2015-03-18 Last updated: 2017-03-27

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Festin, KarinLindström, TorbjörnLänne, TosteNyström, Fredrik HÖstgren, Carl JohanEngvall, Jan

Search in DiVA

By author/editor
Festin, KarinLindström, TorbjörnLänne, TosteNyström, Fredrik HÖstgren, Carl JohanEngvall, Jan
By organisation
Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Community MedicineFaculty of Health SciencesDivision of Cardiovascular MedicineDepartment of EndocrinologyCenter for Medical Image Science and Visualization (CMIV)Department of Thoracic and Vascular SurgeryDepartment of EndocrinologyPrimary Health Care in MotalaDepartment of Clinical Physiology in Linköping
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 242 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf