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Circadian angiogenesis
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pharmacology. Department of Microbiology, Tumor and Cell Biology, The Karolinska Institute, tockholm, Sweden.
The Block Center for Integrative Cancer Treatment, 60077 Skokie, IL, USA.
The Block Center for Integrative Cancer Treatment, 60077 Skokie, IL, USA.
2014 (English)In: Biomolecular concepts, ISSN 1868-503X, Vol. 5, no 3, 245-56 p.Article in journal (Refereed) Published
Abstract [en]

Daily rhythms of light/darkness, activity/rest and feeding/fasting are important in human physiology and their disruption (for example by frequent changes between day and night shifts) increases the risk of disease. Many of the diseases found to be associated with such disrupted circadian lifestyles, including cancer, cardiovascular diseases, metabolic disorders and neurological diseases, depend on pathological de-regulation of angiogenesis, suggesting that disrupting the circadian clock will impair the physiological regulation of angiogenesis leading to development and progression of these diseases. Today there is little known regarding circadian regulation of pathological angiogenesis but there is some evidence that supports both direct and indirect regulation of angiogenic factors by the cellular circadian clock machinery, as well as by circulating circadian factors, important for coordinating circadian rhythms in the organism. Through highlighting recent advances both in pre-clinical and clinical research on various diseases including cancer, cardiovascular disorders and obesity, we will here present an overview of the available knowledge on the importance of circadian regulation of angiogenesis and discuss how the circadian clock may provide alternative targets for pro- or anti-angiogenic therapy in the future.

Place, publisher, year, edition, pages
2014. Vol. 5, no 3, 245-56 p.
Keyword [en]
angiogenesis; cancer; circadian; vascular endothelial growth factor (VEGF); zebrafish
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-115785DOI: 10.1515/bmc-2014-0009PubMedID: 25372756OAI: diva2:796637
Available from: 2015-03-19 Created: 2015-03-19 Last updated: 2015-06-10

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Jensen, Lasse Dahl
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Clinical Pharmacology
Cancer and Oncology

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