liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes
University of Mons UMONS, Belgium.
Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, The Institute of Technology.
University of Montpellier 2, France.
University of Mons UMONS, Belgium.
Show others and affiliations
2015 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 13, no 8, 2453-2463 p.Article in journal (Refereed) Published
Abstract [en]

The molecular recognition of human telomeric G-quadruplexes by a novel cationic pi-extended Ni-II-porphyrin (Ni-II-TImidP4) is studied in aqueous solutions via (chir) optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted Ni-II-porphyrin (Ni-II-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of Ni-II-TImidP4 towards human telomeric G4 than that of Ni-II-TMPyP4.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2015. Vol. 13, no 8, 2453-2463 p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-115832DOI: 10.1039/c4ob02097aISI: 000349669300033PubMedID: 25563845OAI: oai:DiVA.org:liu-115832DiVA: diva2:796802
Note

Funding Agencies|Fonds de la Recherche Scientifique-FNRS (Belgium) [2.4615.11-BINDER]; SeRC (Swedish e-Science Research Center); Swedish Research Council [621-2010-5014]; CNRS; Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0089-01]

Available from: 2015-03-20 Created: 2015-03-20 Last updated: 2017-12-04

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Di Meo, FlorentNorman, PatrickLinares, Mathieu

Search in DiVA

By author/editor
Di Meo, FlorentNorman, PatrickLinares, Mathieu
By organisation
Theoretical ChemistryThe Institute of Technology
In the same journal
Organic and biomolecular chemistry
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 228 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf