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Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes
University of Mons UMONS, Belgium.
Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, The Institute of Technology.
University of Montpellier 2, France.
University of Mons UMONS, Belgium.
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2015 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 13, no 8, 2453-2463 p.Article in journal (Refereed) Published
Abstract [en]

The molecular recognition of human telomeric G-quadruplexes by a novel cationic pi-extended Ni-II-porphyrin (Ni-II-TImidP4) is studied in aqueous solutions via (chir) optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted Ni-II-porphyrin (Ni-II-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of Ni-II-TImidP4 towards human telomeric G4 than that of Ni-II-TMPyP4.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2015. Vol. 13, no 8, 2453-2463 p.
National Category
Chemical Sciences
URN: urn:nbn:se:liu:diva-115832DOI: 10.1039/c4ob02097aISI: 000349669300033PubMedID: 25563845OAI: diva2:796802

Funding Agencies|Fonds de la Recherche Scientifique-FNRS (Belgium) [2.4615.11-BINDER]; SeRC (Swedish e-Science Research Center); Swedish Research Council [621-2010-5014]; CNRS; Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0089-01]

Available from: 2015-03-20 Created: 2015-03-20 Last updated: 2015-03-20

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Di Meo, FlorentNorman, PatrickLinares, Mathieu
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