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MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway.
Department of Chemistry, Bose Institute, Kolkata 700009, India.
Department of Chemistry, Bose Institute, Kolkata 700009, India.
Department of Chemistry, Bose Institute, Kolkata 700009, India.
Department of Chemistry, Bose Institute, Kolkata 700009, India.
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2015 (English)In: Cell host & microbe, ISSN 1934-6069, Vol. 17, no 3, 345-56 p.Article in journal (Refereed) Published
Abstract [en]

The outcome of the interaction between Mycobacterium tuberculosis (Mtb) and a macrophage depends on the interplay between host defense and bacterial immune subversion mechanisms. MicroRNAs critically regulate several host defense mechanisms, but their role in the Mtb-macrophage interplay remains unclear. MicroRNA profiling of Mtb-infected macrophages revealed the downregulation of miR-let-7f in a manner dependent on the Mtb secreted effector ESAT-6. We establish that let-7f targets A20, a feedback inhibitor of the NF-κB pathway. Expression of let-7f decreases and A20 increases with progression of Mtb infection in mice. Mtb survival is attenuated in A20-deficient macrophages, and the production of TNF, IL-1β, and nitrite, which are mediators of immunity to Mtb, is correspondingly increased. Further, let-7f overexpression diminishes Mtb survival and augments the production of cytokines including TNF and IL-1β. These results uncover a role for let-7f and its target A20 in regulating immune responses to Mtb and controlling bacterial burden.

Place, publisher, year, edition, pages
elsevier , 2015. Vol. 17, no 3, 345-56 p.
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-116362DOI: 10.1016/j.chom.2015.01.007ISI: 000350979800013PubMedID: 25683052OAI: oai:DiVA.org:liu-116362DiVA: diva2:798280
Available from: 2015-03-26 Created: 2015-03-26 Last updated: 2015-04-13Bibliographically approved

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Raffetseder, JohannaLerm, Maria

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CiteExportLink to record
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