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The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres
Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France; Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France.
Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France.
Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France; Institute of Biochemistry (IBC), Eidgenössische Technische Hochschule Zürich (ETHZ), Zürich, Switzerland.
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2014 (English)In: Cell Cycle, ISSN 1538-4101, E-ISSN 1551-4005, Vol. 13, no 15, 2469-2479 p.Article in journal (Refereed) Published
Abstract [en]

The stability of mammalian telomeres depends upon TRF2, which prevents inappropriate repair and checkpoint activation. By using a plasmid integration assay in yeasts carrying humanized telomeres, we demonstrated that TRF2 possesses the intrinsic property to both stimulate initial homologous recombination events and to prevent their resolution via its basic N-terminal domain. In human cells, we further showed that this TRF2 domain prevents telomere shortening mediated by the resolvase-associated protein SLX4 as well as GEN1 and MUS81, 2 different types of endonucleases with resolvase activities. We propose that various types of resolvase activities are kept in check by the basic N-terminal domain of TRF2 in order to favor an accurate repair of the stalled forks that occur during telomere replication. © 2014 Landes Bioscience.

Place, publisher, year, edition, pages
Taylor andamp; Francis: STM, Behavioural Science and Public Health Titles , 2014. Vol. 13, no 15, 2469-2479 p.
Keyword [en]
Recombination; Shelterin; Telomere; TRF2
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:liu:diva-116377DOI: 10.4161/cc.29422PubMedID: 25483196Scopus ID: 2-s2.0-84905902302OAI: oai:DiVA.org:liu-116377DiVA: diva2:798833
Available from: 2015-03-27 Created: 2015-03-26 Last updated: 2017-12-04

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