2015 (English)In: Reference module in biomedical sciences, Elsevier, 2015, 413-438 p.Chapter in book (Refereed)
Models of autoimmunity fall into four categories: (a) those induced by immunization with self-antigen, (b) those induced by exogenous agents, (c) those which arise spontaneously, and (d) those which are produced by genetic manipulation. The autoimmunity exhibited by these models covers a spectrum of diseases which fall into the two broad categories, organ-specific and systemic autoimmunity. Animal models of autoimmune diseases have played an essential role in the discovery of many of mechanisms that result in the breaking of self-tolerance. This chapter describes a number of experimental animal models of autoimmunity and the underlying mechanisms that lead to disease.
Place, publisher, year, edition, pages
Elsevier, 2015. 413-438 p.
Animal model; Autoimmunity; Chemical-induced; Diabetes; Encephalomyelitis; Gastritis; Immune tolerance; Lupus; Mercury; Metal; Nephritis; Silica; Thyroiditis
Immunology in the medical area
IdentifiersURN: urn:nbn:se:liu:diva-116714ISBN: 9780128012383OAI: oai:DiVA.org:liu-116714DiVA: diva2:800131