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Autoimmune models
University of California, San Diego, CA, USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
The Scripps Research Institute, La Jolla, CA, USA.
2015 (English)In: Reference module in biomedical sciences, Elsevier, 2015, 413-438 p.Chapter in book (Refereed)
Abstract [en]

Models of autoimmunity fall into four categories: (a) those induced by immunization with self-antigen, (b) those induced by exogenous agents, (c) those which arise spontaneously, and (d) those which are produced by genetic manipulation. The autoimmunity exhibited by these models covers a spectrum of diseases which fall into the two broad categories, organ-specific and systemic autoimmunity. Animal models of autoimmune diseases have played an essential role in the discovery of many of mechanisms that result in the breaking of self-tolerance. This chapter describes a number of experimental animal models of autoimmunity and the underlying mechanisms that lead to disease.

Place, publisher, year, edition, pages
Elsevier, 2015. 413-438 p.
Keyword [en]
Animal model; Autoimmunity; Chemical-induced; Diabetes; Encephalomyelitis; Gastritis; Immune tolerance; Lupus; Mercury; Metal; Nephritis; Silica; Thyroiditis
National Category
Immunology in the medical area
URN: urn:nbn:se:liu:diva-116714ISBN: 9780128012383OAI: diva2:800131
Available from: 2015-04-01 Created: 2015-04-01 Last updated: 2016-02-12Bibliographically approved

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Hultman, Per
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Clinical Pathology and Clinical Genetics
Immunology in the medical area

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