Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques
2015 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 20, no 2, 020503- p.Article in journal (Refereed) Published
Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.
Place, publisher, year, edition, pages
Society of Photo-optical Instrumentation Engineers (SPIE) , 2015. Vol. 20, no 2, 020503- p.
atherosclerosis; electronic paramagnetic resonance imaging; polarimetry; nonlinear optical microscopy
Clinical Medicine Chemical Sciences Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:liu:diva-116839DOI: 10.1117/1.JBO.20.2.020503ISI: 000350462900003PubMedID: 25714991OAI: oai:DiVA.org:liu-116839DiVA: diva2:800634
Funding Agencies|Swedish Research Council [diarienr 2009-5430]2015-04-072015-04-072016-02-15