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Peripheral nerve as an osmometer: role of the perineurium in frog sciatic nerve.
Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, The Institute of Technology.
1983 (English)In: American Journal of Physiology, ISSN 0002-9513, Vol. 244, no 1, C75-81 p.Article in journal (Refereed) Published
Abstract [en]

Measurements of volume and hydrostatic pressure in the frog sciatic nerve in vitro demonstrate that the nerve acts as an osmometer, in large part because the perineurium is a semipermeable membrane for water flow. Endoneurial hydrostatic pressure in nerves in isotonic Ringer exceeds bath pressure by about 7 mmHg. In Ringer made hypertonic by addition of sucrose, nerve volume and endoneurial pressure fall linearly in relation to 1/osmolality. The slope of the plot of pressure against volume provides a value for nerve compliance equal to 0.006 mm2/mmHg. Calculations based on the model of the nerve as an osmometer indicate that the nerve has an osmotically "inactive" volume equal to 0.19 mm3/mm, which is about 75% of the total volume of a nerve segment of unit length in normal Ringer. Perineurial hydraulic conductivity (Lp) equals 7.5 x 10(-13) cm3.s-1.dyn-1, a value characteristic of nonleaky epithelia. The perineurium is an elastic tissue with a constant modulus of elasticity equal to 3 x 10(6) dyn/cm2 when not markedly stretched and may limit nerve swelling under pathological conditions of nerve edema.

Place, publisher, year, edition, pages
1983. Vol. 244, no 1, C75-81 p.
National Category
Geotechnical Engineering
URN: urn:nbn:se:liu:diva-116876PubMedID: 6600373OAI: diva2:801203
Available from: 2015-04-08 Created: 2015-04-08 Last updated: 2015-04-17

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