liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Mathematical model that characterizes transmitral and pulmonary venous flow velocity patterns.
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology.
Show others and affiliations
1995 (English)In: American Journal of Physiology, ISSN 0002-9513, Vol. 268, no 1 Pt 2, H476-89 p.Article in journal (Refereed) Published
Abstract [en]

The transmitral and pulmonary venous flow velocity (TMFV and PVFV, respectively) patterns are related to the physiological state of the left heart by use of an electrical analog model. Filling of left ventricle (LV) through the mitral valve is characterized by a quadratic Bernoulli's resistance in series with an inertance. Filling of the left atrium (LA) through the pulmonary veins is represented by a lumped network of linear resistance, capacitance, and inertance. LV and LA are each represented by a time-varying elastance. A volume dependency is incorporated into the LV model to produce physiological pressure-volume loops and Starling curves. The state-space representation of the analog model consists of 10 simultaneous differential equations, which are solved by numerical integration. Model validity is supported by the following. First, the expected effects of aging and decreasing LV compliance on TMFV and PVFV are accurately represented by the model. Second, the model-generated TMFV and PVFV waveforms fit well to pulsed-Doppler recordings in normal and postinfarct patients. It is shown that the TMFV deceleration time is prolonged by the increase in LV compliance and, to a lesser extent, by the increase in LA compliance. A shift from diastolic dominance to systolic dominance in PVFV occurs when LA compliance or pulmonary perfusion pressure increases or when LV compliance or mitral valve area decreases. The present model should serve as a useful theoretical basis for echocardiographic evaluation of LV and LA functions.

Place, publisher, year, edition, pages
1995. Vol. 268, no 1 Pt 2, H476-89 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-116901PubMedID: 7840296OAI: diva2:801437
Available from: 2015-04-09 Created: 2015-04-09 Last updated: 2015-04-20

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Sjöberg, Birgitta JaneroAsk, PerLoyd, DanWranne, Bengt
By organisation
Clinical PhysiologyFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in LinköpingPhysiological MeasurementsThe Institute of TechnologyApplied Thermodynamics and Fluid MechanicsClinical Physiology
In the same journal
American Journal of Physiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 128 hits
ReferencesLink to record
Permanent link

Direct link