Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels
2015 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 131, no 4, 269-278 p.Article in journal (Refereed) Published
ObjectiveRecent studies indicate that inflammation may play a role in the pathophysiology of suicidality. Interleukin-8 (IL-8) is a chemokine that in addition to its function in the immune system also exert neuroprotective properties. The involvement of this chemokine in neuropsychiatric conditions is incompletely known. MethodWe measured plasma and cerebrospinal fluid (CSF) IL-8, as well as the genotype frequency of a single nucleotide polymorphism (-251A/T, rs4073) in the promoter region of the IL8 gene, in suicide attempters (n=206) and healthy controls (n=578). ResultsPlasma and CSF levels of IL-8 were significantly lower in suicide attempters with anxiety than in healthy controls. IL-8 in both plasma and CSF correlated negatively with symptoms of anxiety. Compared with the population-based cohort, the IL-8-251T allele was more prevalent among female suicide attempters. Furthermore, suicide attempters carrying this allele showed more severe anxiety. This correlative study warrants further mechanistic studies on the effects of IL-8 in the central nervous system. ConclusionWe suggest that IL-8 might be involved in the biological mechanisms mediating resilience to anxiety. Thus, our findings highlight the chemokine IL-8 as a potential target for future development of anti-anxiety treatments and suicide prevention.
Place, publisher, year, edition, pages
Wiley: 12 months , 2015. Vol. 131, no 4, 269-278 p.
depression; inflammation; chemokine; biomarker
IdentifiersURN: urn:nbn:se:liu:diva-116942DOI: 10.1111/acps.12339ISI: 000351147200008PubMedID: 25251027OAI: oai:DiVA.org:liu-116942DiVA: diva2:802521
Funding Agencies|Swedish Research Council [2009-7052, 2013-2838]; Swedish Brain Foundation; Soderstrom-Konig Foundation; Sjobring Foundation; Fysiografiska Society; province of Scania state grants (ALF)2015-04-132015-04-102016-03-24