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Body size and the risk of multiple sclerosis in Norway and Italy: The EnvIMS study.
University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway .
University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway.
Section of Clinical Neurology, University of Ferrara, Italy.
Clinic of Neurology, Faculty of Medicine, University of Belgrade, Serbia.
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2015 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 21, no 4, 388-395 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Obesity may be a risk factor for developing multiple sclerosis (MS).

OBJECTIVE: We examined if body size influences the risk of MS in a population-based, case control study.

METHODS: A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity.

RESULTS: In Norway a large body size (silhouettes 6-9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09-4.46 for men and OR 1.43; 95% CI 0.90-2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68-4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy.

CONCLUSIONS: Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.

Place, publisher, year, edition, pages
2015. Vol. 21, no 4, 388-395 p.
Keyword [en]
Multiple sclerosis; body mass index; body size; case control studies; epidemiology; obesity; vitamin D
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-117084DOI: 10.1177/1352458514546785ISI: 000352165000007PubMedID: 25182290OAI: diva2:805448
Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2015-05-11

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Landtblom, Anne-Marie
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Division of Neuro and Inflammation ScienceFaculty of Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Neurology
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