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NMR diffusion-encoding with axial symmetry and variable anisotropy: Distinguishing between prolate and oblate microscopic diffusion tensors with unknown orientation distribution
Lund University, Sweden.
CR Dev AB, Sweden.
Lund University, Sweden.
Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Harvard University, MA 02215 USA.
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2015 (English)In: Journal of Chemical Physics, ISSN 0021-9606, E-ISSN 1089-7690, Vol. 142, no 10, 104201- p.Article in journal (Refereed) Published
Abstract [en]

We introduce a nuclear magnetic resonance method for quantifying the shape of axially symmetric microscopic diffusion tensors in terms of a new diffusion anisotropy metric, D-Delta, which has unique values for oblate, spherical, and prolate tensor shapes. The pulse sequence includes a series of equal-amplitude magnetic field gradient pulse pairs, the directions of which are tailored to give an axially symmetric diffusion-encoding tensor b with variable anisotropy b(Delta). Averaging of data acquired for a range of orientations of the symmetry axis of the tensor b renders the method insensitive to the orientation distribution function of the microscopic diffusion tensors. Proof-of-principle experiments are performed on water in polydomain lyotropic liquid crystals with geometries that give rise to microscopic diffusion tensors with oblate, spherical, and prolate shapes. The method could be useful for characterizing the geometry of fluid-filled compartments in porous solids, soft matter, and biological tissues. (C) 2015 Author(s).

Place, publisher, year, edition, pages
American Institute of Physics (AIP) , 2015. Vol. 142, no 10, 104201- p.
National Category
Medical Biotechnology
URN: urn:nbn:se:liu:diva-117230DOI: 10.1063/1.4913502ISI: 000350978000046PubMedID: 25770532OAI: diva2:807101

Funding Agencies|Swedish Foundation for Strategic Research [AM13-0090]; Swedish Research Council [2009-6794, 2014-3910, K2011-52x-21737-01-3]; Swedish Cancer Society [04 0421]; National Institute of Health (NIH) [R01MH074794, P41EB015902]

Available from: 2015-04-22 Created: 2015-04-21 Last updated: 2015-04-22

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Westin, Carl-Fredrik
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