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Why organisms age: Evolution of senescence under positive pleiotropy?
Uppsala University, Uppsala, Sweden.
University of Toronto, Toronto, ON, Canada.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-6112-9586
2015 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 37, no 7, 802-807 p.Article in journal (Refereed) Published
Abstract [en]

Two classic theories maintain that aging evolves eitherbecause of alleles whose deleterious effects are confinedto late life or because of alleles with broad pleiotropiceffects that increase early-life fitness at the expense oflate-life fitness. However, empirical studies often revealpositive pleiotropy for fitness across age classes, andrecent evidence suggests that selection on early-lifefitness can decelerate aging and increase lifespan, therebycasting doubt on the current consensus. Here, we brieflyreview these data and promote the simple argument thataging can evolve under positive pleiotropy between earlyandlate-life fitness when the deleterious effect ofmutations increases with age. We argue that thishypothesis makes testable predictions and is supportedby existing evidence.

Place, publisher, year, edition, pages
Wiley Periodicals, Inc. , 2015. Vol. 37, no 7, 802-807 p.
Keyword [en]
Aging; life-history evolution; mutation accumulation; positive pleiotropy; senescence
National Category
Evolutionary Biology
URN: urn:nbn:se:liu:diva-117545DOI: 10.1002/bies.201500025ISI: 000356827700012PubMedID: 25900580OAI: diva2:809449
Available from: 2015-05-04 Created: 2015-05-04 Last updated: 2016-05-25

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