liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Magneto-fluorescent nanoparticles with high-intensity NIR emission, T-1-and T-2-weighted MR for multimodal specific tumor imaging
Liaoning Medical University, Peoples R China; Liaoning Medical University, Peoples R China.
University of Macau, Peoples R China.
Liaoning Medical University, Peoples R China; Liaoning Medical University, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Show others and affiliations
2015 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 3, no 15, 3072-3080 p.Article in journal (Refereed) Published
Abstract [en]

Nanoparticles exhibiting bright near-infrared (NIR) fluorescence, T-1-and T-2-weighted MR were synthesized for specific tumor imaging. Clinically used Fe3O4 nanoparticles exhibit an intrinsic dark signal (T-2-weighted MRI), which sometimes misleads clinical diagnosis. Here, for the first time we integrated ultrasmall Fe3O4 nanoparticles (2-3 nm) with an NIR emitting semiconducting polymer for both T-1-and T-2-weighted MRI as well as fluorescence imaging of tumors. Bio-functionalized multi-modality fluorescent magnetic nanoparticles (FMNPs) functionalized with folic acid exhibit bright fluorescence and high relaxation (r(1) = 7.008 mM(-1) s(-1), r(2) = 26.788 mM(-1) s(-1), r(2)/r(1) = 3.8). These FMNPs have a small average dynamic size of about 20 nm with low aggregation and long circulation time. In vitro studies revealed that FMNPs can serve as an effective fluorescent probe to achieve targeting images of human A549 lung cancer cells without obvious cytotoxicity. In vivo experimental results show that the FMNPs are able to preferentially accumulate in tumor tissues for specific fluorescence imaging, T-1-and T-2-weighted MRI.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2015. Vol. 3, no 15, 3072-3080 p.
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-117672DOI: 10.1039/c5tb00155bISI: 000352287400018OAI: oai:DiVA.org:liu-117672DiVA: diva2:811290
Note

Funding Agencies|National Natural Science Foundation of China [81401499, 81171799]; Linkoping Integrative Regenerative Medicine Center [1258000107]

Available from: 2015-05-11 Created: 2015-05-06 Last updated: 2015-05-25

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hu, Zhang-JunUvdal, Kajsa
By organisation
Molecular Surface Physics and Nano ScienceFaculty of Science & Engineering
In the same journal
Journal of materials chemistry. B
Physical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 80 hits
ReferencesLink to record
Permanent link

Direct link