Is aortic wall shear stress affected by aging? An image-based numerical study with two age groups
2015 (English)In: Medical Engineering and Physics, ISSN 1350-4533, E-ISSN 1873-4030, Vol. 37, no 3, 265-271 p.Article in journal (Refereed) Published
The size of the larger arteries increases during the entire life, but not much is known about how the change in size affects the blood flow. This study compares the flow field in a group of young males (N = 10, age = 23.5 +/- 1.4), with a group of older males (N = 8, age = 58.0 +/- 2.8). Aortic geometries were obtained by magnetic resonance imaging, and the aortic blood flow field was computed using computational fluid dynamics. The aortic wall shear stress was obtained from the computations, and it was concluded that time-averaged wall shear stress decreased with increased age, probably as a consequence of increased aortic diameter and decreased stroke volume, which in turn reduces the shear rates in the aorta. However, the oscillatory shear index, which is a measure of the oscillatory nature of the wall shear stress vector, seemed to be unaffected by aging.
Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 37, no 3, 265-271 p.
Aorta; Wall shear stress; Oscillatory shear index; Computational fluid dynamics; Aging; Magnetic resonance imaging
Mechanical Engineering Clinical Medicine
IdentifiersURN: urn:nbn:se:liu:diva-117663DOI: 10.1016/j.medengphy.2014.12.011ISI: 000352249800002PubMedID: 25630809OAI: oai:DiVA.org:liu-117663DiVA: diva2:811427
Funding Agencies|Swedish e-Science Research Centre; Centre for Industrial Information Technology [99.11]; Swedish Research Council [2010-4282]; Swedish Heart and Lung Foundation2015-05-122015-05-062016-03-14