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Is aortic wall shear stress affected by aging? An image-based numerical study with two age groups
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Science & Engineering. Swedish E Science Research Centre SeRC, Sweden.ORCID iD: 0000-0003-1942-7699
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-5526-2399
2015 (English)In: Medical Engineering and Physics, ISSN 1350-4533, E-ISSN 1873-4030, Vol. 37, no 3, 265-271 p.Article in journal (Refereed) Published
Abstract [en]

The size of the larger arteries increases during the entire life, but not much is known about how the change in size affects the blood flow. This study compares the flow field in a group of young males (N = 10, age = 23.5 +/- 1.4), with a group of older males (N = 8, age = 58.0 +/- 2.8). Aortic geometries were obtained by magnetic resonance imaging, and the aortic blood flow field was computed using computational fluid dynamics. The aortic wall shear stress was obtained from the computations, and it was concluded that time-averaged wall shear stress decreased with increased age, probably as a consequence of increased aortic diameter and decreased stroke volume, which in turn reduces the shear rates in the aorta. However, the oscillatory shear index, which is a measure of the oscillatory nature of the wall shear stress vector, seemed to be unaffected by aging.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 37, no 3, 265-271 p.
Keyword [en]
Aorta; Wall shear stress; Oscillatory shear index; Computational fluid dynamics; Aging; Magnetic resonance imaging
National Category
Mechanical Engineering Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-117663DOI: 10.1016/j.medengphy.2014.12.011ISI: 000352249800002PubMedID: 25630809OAI: oai:DiVA.org:liu-117663DiVA: diva2:811427
Note

Funding Agencies|Swedish e-Science Research Centre; Centre for Industrial Information Technology [99.11]; Swedish Research Council [2010-4282]; Swedish Heart and Lung Foundation

Available from: 2015-05-12 Created: 2015-05-06 Last updated: 2016-03-14

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Lantz, JonasRenner, JohanLänne, TosteKarlsson, Matts
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Division of Cardiovascular MedicineFaculty of Science & EngineeringApplied Thermodynamics and Fluid MechanicsCenter for Medical Image Science and Visualization (CMIV)Faculty of Health SciencesDepartment of Thoracic and Vascular Surgery
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