liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Therapy using implanted organic bioelectronics
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. (Laboratory of Organic Electronics)
Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Acreo Swedish ICT AB, SE-601 17 Norrköping, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Show others and affiliations
2015 (English)In: Science Advances, ISSN 2375-2548, Vol. 1, no 4, e1500039Article in journal (Refereed) Published
Abstract [en]

Many drugs provide their therapeutic action only at specific sites in the body, but are administered in ways that cause the drug’s spread throughout the organism. This can lead to serious side effects. Local delivery from an implanted device may avoid these issues, especially if the delivery rate can be tuned according to the need of the patient. We turned to electronically and ionically conducting polymers to design a device that could be implanted and used for local electrically controlled delivery of therapeutics. The conducting polymers in our device allow electronic pulses to be transduced into biological signals, in the form of ionic and molecular fluxes, which provide a way of interfacing biology with electronics. Devices based on conducting polymers and polyelectrolytes have been demonstrated in controlled substance delivery to neural tissue, biosensing, and neural recording and stimulation. While providing proof of principle of bioelectronic integration, such demonstrations have been performed in vitro or in anesthetized animals. Here, we demonstrate the efficacy of an implantable organic electronic delivery device for the treatment of neuropathic pain in an animal model. Devices were implanted onto the spinal cord of rats, and 2 days after implantation, local delivery of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) was initiated. Highly localized delivery resulted in a significant decrease in pain response with low dosage and no observable side effects. This demonstration of organic bioelectronics-based therapy in awake animals illustrates a viable alternative to existing pain treatments, paving the way for future implantable bioelectronic therapeutics. Keywords

Place, publisher, year, edition, pages
2015. Vol. 1, no 4, e1500039
Keyword [en]
pain, neuromodulation, in vivo, organic electronics, bioelectronics
National Category
Textile, Rubber and Polymeric Materials Medical Materials Other Medical Biotechnology
Identifiers
URN: urn:nbn:se:liu:diva-117968DOI: 10.1126/sciadv.1500039OAI: oai:DiVA.org:liu-117968DiVA: diva2:812511
Projects
OBOE miljö
Funder
VINNOVA, 2010-00507
Available from: 2015-05-19 Created: 2015-05-19 Last updated: 2017-02-03
In thesis
1. Organic electronics for precise delivery of neurotransmitters
Open this publication in new window or tab >>Organic electronics for precise delivery of neurotransmitters
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Organic electronic materials, that is, carbon-based compounds that conduct electricity, have emerged as candidates for improving the interface between conventional electronics and biological systems. The softness of these materials matches the elasticity of biological tissue better than conventional electronic conductors, allowing better contact to tissue, and the mixed ionic-electronic conductivity can improve the signal transduction between electronic devices and electrically excitable cells. This improved communication between electronics and tissue can significantly enhance, for example, electrical stimulation for therapy and electrical recording for diagnostics.

The ionic conductivity of organic electronic materials makes it possible to achieve ion-specific ionic currents, where the current consists of migration of specific ions. These ions can be charged signalling substances, such as neurotransmitters, that can selectively activate or inhibit cells that contain receptors for these substances. This thesis describes the development of chemical delivery devices, where delivery is based on such ion-specific currents through ionically and electronically conducting polymers. Delivery is controlled by electrical signals, and allows release of controlled amounts of neurotransmitters, or other charged compounds, to micrometer-sized regions.

The aims of the thesis have been to improve spatial control and temporal resolution of chemical delivery, with the ultimate goal of selective interaction with individual cells, and to enable future therapies for disorders of the nervous system. Within the thesis, we show that delivery can alleviate pain through local delivery to specific regions of the spinal cord in an animal model of neuropathic pain, and that epilepsy-related signalling can be suppressed in vitro. We also integrate the delivery device with electrodes for sensing, to allow simultaneous electrical recording and delivery at the same position. Finally, we improve the delay from electrical signal to chemical delivery, approaching the time domain of synaptic signaling, and construct devices with several individually controlled release sites.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2016. 108 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1817
National Category
Textile, Rubber and Polymeric Materials Condensed Matter Physics Biomedical Laboratory Science/Technology Materials Chemistry Neurosciences
Identifiers
urn:nbn:se:liu:diva-133164 (URN)10.3384/diss.diva-133164 (DOI)978-91-7685-616-1 (ISBN)
Public defence
2017-01-11, Kåkenhus sal K3 (Önnesjösalen), Linköpings Universitet, Norrköping, 10:00 (English)
Opponent
Supervisors
Available from: 2016-12-12 Created: 2016-12-12 Last updated: 2017-02-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full texthttp://dx.doi.org/10.1126/sciadv.1500039

Search in DiVA

By author/editor
Jonsson, AmandaSimon, DanielBerggren, Magnus
By organisation
Physics and ElectronicsFaculty of Science & Engineering
Textile, Rubber and Polymeric MaterialsMedical MaterialsOther Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 1950 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf