A potential-gated molecularly imprinted smart electrode for nicotinamide analysis
2015 (English)In: RSC Advances, ISSN 2046-2069, Vol. 5, no 44, 35089-35096 p.Article in journal (Refereed) Published
Triggered surface responsiveness paves the way for smart sensor technologies that not only have tunable retention, but also provide sensing through a built-in programming of electrode material. In this study, we report a potential-gated electrochemical sensor for determination of nicotinamide (NAM) based on a molecularly imprinted overoxidised polypyrrole electrode. The sensitive layer was prepared by electropolymerisation of pyrrole on a glassy carbon electrode in the presence of NAM as a template molecule, followed by alkali extraction. Electrochemical methods were used to monitor the processes of electropolymerisation, template removal and binding in the presence of a [Fe(CN)(6)](3-)/[Fe(CN)(6)](4-) redox couple as an electrochemical probe. Several factors affecting the performance of the MIP-modified electrode were investigated and optimized. The peak current of the ferro/ferricyanide couple decreased linearly with successive addition of NAM in the concentration range 0.9 x 10(-6) to 9.9 x 10(-3) M with a detection limit of 1.7 x 10(-7) M (S/N = 3). The molecularly-imprinted polymer (MIP) electrode had excellent recognition capability for NAM compared to structurally related molecules. Moreover, the reproducibility and repeatability of the NAM-imprinted electrode were all found to be satisfactory. The results from sample analysis confirmed the applicability of the NAM-imprinted electrode to reusable quantitative analysis in commercial pharmaceutical samples.
Place, publisher, year, edition, pages
Royal Society of Chemistry , 2015. Vol. 5, no 44, 35089-35096 p.
IdentifiersURN: urn:nbn:se:liu:diva-118069DOI: 10.1039/c5ra02697kISI: 000353168300072OAI: oai:DiVA.org:liu-118069DiVA: diva2:812857
Funding Agencies|Swedish Research Council [VR-2011-6058357]; Ferdowsi University of Mashhad, Iran2015-05-202015-05-202015-05-20