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A potential-gated molecularly imprinted smart electrode for nicotinamide analysis
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology. Ferdowsi University of Mashhad, Iran.
Ferdowsi University of Mashhad, Iran.
Ferdowsi University of Mashhad, Iran.
Ferdowsi University of Mashhad, Iran.
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2015 (English)In: RSC Advances, ISSN 2046-2069, Vol. 5, no 44, 35089-35096 p.Article in journal (Refereed) Published
Abstract [en]

Triggered surface responsiveness paves the way for smart sensor technologies that not only have tunable retention, but also provide sensing through a built-in programming of electrode material. In this study, we report a potential-gated electrochemical sensor for determination of nicotinamide (NAM) based on a molecularly imprinted overoxidised polypyrrole electrode. The sensitive layer was prepared by electropolymerisation of pyrrole on a glassy carbon electrode in the presence of NAM as a template molecule, followed by alkali extraction. Electrochemical methods were used to monitor the processes of electropolymerisation, template removal and binding in the presence of a [Fe(CN)(6)](3-)/[Fe(CN)(6)](4-) redox couple as an electrochemical probe. Several factors affecting the performance of the MIP-modified electrode were investigated and optimized. The peak current of the ferro/ferricyanide couple decreased linearly with successive addition of NAM in the concentration range 0.9 x 10(-6) to 9.9 x 10(-3) M with a detection limit of 1.7 x 10(-7) M (S/N = 3). The molecularly-imprinted polymer (MIP) electrode had excellent recognition capability for NAM compared to structurally related molecules. Moreover, the reproducibility and repeatability of the NAM-imprinted electrode were all found to be satisfactory. The results from sample analysis confirmed the applicability of the NAM-imprinted electrode to reusable quantitative analysis in commercial pharmaceutical samples.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2015. Vol. 5, no 44, 35089-35096 p.
National Category
Biological Sciences
URN: urn:nbn:se:liu:diva-118069DOI: 10.1039/c5ra02697kISI: 000353168300072OAI: diva2:812857

Funding Agencies|Swedish Research Council [VR-2011-6058357]; Ferdowsi University of Mashhad, Iran

Available from: 2015-05-20 Created: 2015-05-20 Last updated: 2015-05-20

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