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Health-related quality of life in women referred for bone density assessment: relationships with bone mineral density, fracture and co-morbidity
Bangor University, Wales.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
Robert Jones and Agnes Hunt Orthopaed Hospital NHS Fdn, England.
2015 (English)In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 24, no 5, 1235-1243 p.Article in journal (Refereed) Published
Abstract [en]

To identify variables that might influence health-related quality of life (HRQoL) in patients with and without a history of fracture, attending bone mineral density (BMD) assessment prior to diagnosis of osteoporosis. This cross-sectional study included 312 newly referred postmenopausal women attending for a DXA scan, without a diagnosis of osteoporosis. Data were obtained from the medical history and the General Practitioners letter. HRQoL, using SF36 was scored using published algorithms with reference to an age-related population from England. Regression analyses were used to determine relationships between HRQoL and BMD, age, fracture status and co-morbidities. For all patients, the age-related physical component summary (PCS) and mental component summary (MCS) scores were 46 +/- A 10 and 47 +/- A 10, respectively. Controlling for confounding variables, low BMD at the femoral neck was associated with worse PCS scores (p = 0.010) and MCS scores (p = 0.034) in patients without fracture. In patients with a history of fracture, this relationship was less evident, and younger age (p less than 0.00), increasing BMI (p = 0.016) and number of co-morbidities (p = 0.042) were associated with reductions in PCS scores. Patients referred for BMD assessment before a diagnosis of osteoporosis had reduced PCS scores. In patients without fracture, low BMD contributed to this reduction in health-related quality of life. Low PCS scores in patients with fracture were seen only in younger subjects with osteoporosis.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2015. Vol. 24, no 5, 1235-1243 p.
Keyword [en]
Bone density; Osteoporosis; Fracture; HRQoL; SF36
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-118044DOI: 10.1007/s11136-014-0851-0ISI: 000353209500021PubMedID: 25413779OAI: oai:DiVA.org:liu-118044DiVA: diva2:812999
Note

Funding Agencies|Charles Salt Trust

Available from: 2015-05-21 Created: 2015-05-20 Last updated: 2015-05-21

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Sharp, Christopher
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