Health-related quality of life in women referred for bone density assessment: relationships with bone mineral density, fracture and co-morbidity
2015 (English)In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 24, no 5, 1235-1243 p.Article in journal (Refereed) Published
To identify variables that might influence health-related quality of life (HRQoL) in patients with and without a history of fracture, attending bone mineral density (BMD) assessment prior to diagnosis of osteoporosis. This cross-sectional study included 312 newly referred postmenopausal women attending for a DXA scan, without a diagnosis of osteoporosis. Data were obtained from the medical history and the General Practitioners letter. HRQoL, using SF36 was scored using published algorithms with reference to an age-related population from England. Regression analyses were used to determine relationships between HRQoL and BMD, age, fracture status and co-morbidities. For all patients, the age-related physical component summary (PCS) and mental component summary (MCS) scores were 46 +/- A 10 and 47 +/- A 10, respectively. Controlling for confounding variables, low BMD at the femoral neck was associated with worse PCS scores (p = 0.010) and MCS scores (p = 0.034) in patients without fracture. In patients with a history of fracture, this relationship was less evident, and younger age (p less than 0.00), increasing BMI (p = 0.016) and number of co-morbidities (p = 0.042) were associated with reductions in PCS scores. Patients referred for BMD assessment before a diagnosis of osteoporosis had reduced PCS scores. In patients without fracture, low BMD contributed to this reduction in health-related quality of life. Low PCS scores in patients with fracture were seen only in younger subjects with osteoporosis.
Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2015. Vol. 24, no 5, 1235-1243 p.
Bone density; Osteoporosis; Fracture; HRQoL; SF36
IdentifiersURN: urn:nbn:se:liu:diva-118044DOI: 10.1007/s11136-014-0851-0ISI: 000353209500021PubMedID: 25413779OAI: oai:DiVA.org:liu-118044DiVA: diva2:812999
Funding Agencies|Charles Salt Trust2015-05-212015-05-202015-05-21