Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents
2015 (English)In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, Vol. 232, no 2, 168-174 p.Article in journal (Refereed) Published
The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.
Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 232, no 2, 168-174 p.
ADHD; Adolescents; Dimensionality; DTI; Superior longitudinal fasciculus
IdentifiersURN: urn:nbn:se:liu:diva-118025DOI: 10.1016/j.pscychresns.2015.02.009ISI: 000353625700005PubMedID: 25795595OAI: oai:DiVA.org:liu-118025DiVA: diva2:813116
Funding Agencies|National Institute of Mental Health [K23MH070036]2015-05-212015-05-202015-05-28