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Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Health Sciences.
Hartford Hospital, CT 06106 USA; Yale University, CT 06511 USA.
2015 (English)In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, Vol. 232, no 2, 168-174 p.Article in journal (Refereed) Published
Abstract [en]

The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 232, no 2, 168-174 p.
Keyword [en]
ADHD; Adolescents; Dimensionality; DTI; Superior longitudinal fasciculus
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-118025DOI: 10.1016/j.pscychresns.2015.02.009ISI: 000353625700005PubMedID: 25795595OAI: diva2:813116

Funding Agencies|National Institute of Mental Health [K23MH070036]

Available from: 2015-05-21 Created: 2015-05-20 Last updated: 2015-05-28

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Witt, Suzanne Tyson
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Center for Medical Image Science and Visualization (CMIV)Faculty of Health Sciences
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