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Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage
Newcastle University, England.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine. Linköping University, Faculty of Medicine and Health Sciences.
2015 (English)In: Journal of Reproductive Immunology, ISSN 0165-0378, E-ISSN 1872-7603, Vol. 108, 83-89 p.Article in journal (Refereed) Published
Abstract [en]

The establishment of pregnancy requires the co-ordinated implantation of the embryo into the receptive decidua, placentation, trophoblast invasion of the maternal decidua and myometrium in addition to remodelling of the uterine spiral arteries. Failure of any of these steps can lead to a range of pregnancy complications, including miscarriage, pre-eclampsia, fetal growth restriction, placenta accreta and pre-term birth. Cytokines are small multifunctional proteins often derived from leucocytes and have primarily been described through their immunomodulatory actions. The maternal-fetal interface is considered to be immunosuppressed to allow development of the semi-allogeneic placental fetal unit. However, cytokine profiles of the decidua and different decidual cell types suggest that the in vivo situation might be more complex. Data suggest that decidual-derived cytokines not only play roles in immunosuppression, but also in other aspects of the establishment of pregnancy, including the regulation of trophoblast invasion and spiral artery remodelling. This review focuses on the potential role of decidua-derived cytokines in the aetiology of unexplained spontaneous miscarriage. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 108, 83-89 p.
Keyword [en]
Decidua; Cytokines; Miscarriage; Trophoblast invasion; Spiral artery remodelling
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-118252DOI: 10.1016/j.jri.2015.02.003ISI: 000353602500012PubMedID: 25771398OAI: diva2:813531
Available from: 2015-05-22 Created: 2015-05-22 Last updated: 2015-08-26

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Ernerudh, Jan
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Division of Neuro and Inflammation ScienceDepartment of Clinical Immunology and Transfusion MedicineFaculty of Medicine and Health Sciences
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