Sealing of Submicrometer Wells by a Shear-Driven Lipid Bilayer
2010 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 10, no 5, 1900-1906 p.Article in journal (Refereed) Published
A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.
Place, publisher, year, edition, pages
American Chemical Society , 2010. Vol. 10, no 5, 1900-1906 p.
Spreading lipid bilayers; black lipid membranes; microfluidics; molecule encapsulation; nanostructures
IdentifiersURN: urn:nbn:se:liu:diva-118824DOI: 10.1021/nl100779kISI: 000277444900062PubMedID: 20405904OAI: oai:DiVA.org:liu-118824DiVA: diva2:817143
Funding Agencies|Swedish Research Council for Engineering Sciences [2005-3140]; Swedish Strategic Research Foundation; Royal Physiographic Society in Lund2015-06-042015-06-042015-06-18