Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
2015 (English)In: PHOTONIC THERAPEUTICS AND DIAGNOSTICS XI, Society of Photo-optical Instrumentation Engineers (SPIE) , 2015, Vol. 9303, no 93031L, 93031L- p.Conference paper (Refereed)
In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 - 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.
Place, publisher, year, edition, pages
Society of Photo-optical Instrumentation Engineers (SPIE) , 2015. Vol. 9303, no 93031L, 93031L- p.
, Proceedings of SPIE, ISSN 0277-786X ; 9303
Optical coherence tomography; optical interferometry; phase-sensitive Fourier domain OCT; cochlear vibration; biomedical optical imaging; speech
IdentifiersURN: urn:nbn:se:liu:diva-119274DOI: 10.1117/12.2079673ISI: 000354366400026ISBN: 978-1-62841-393-9OAI: oai:DiVA.org:liu-119274DiVA: diva2:820535
Conference on Photonic Therapeutics and Diagnostics XI