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Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
Oregon Health and Science University, OR 97239 USA.
Oregon Health and Science University, OR 97239 USA.
Oregon Health and Science University, OR 97239 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2015 (English)In: PHOTONIC THERAPEUTICS AND DIAGNOSTICS XI, Society of Photo-optical Instrumentation Engineers (SPIE) , 2015, Vol. 9303, no 93031L, 93031L- p.Conference paper (Refereed)
Abstract [en]

In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 - 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.

Place, publisher, year, edition, pages
Society of Photo-optical Instrumentation Engineers (SPIE) , 2015. Vol. 9303, no 93031L, 93031L- p.
Series
, Proceedings of SPIE, ISSN 0277-786X ; 9303
Keyword [en]
Optical coherence tomography; optical interferometry; phase-sensitive Fourier domain OCT; cochlear vibration; biomedical optical imaging; speech
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-119274DOI: 10.1117/12.2079673ISI: 000354366400026ISBN: 978-1-62841-393-9OAI: oai:DiVA.org:liu-119274DiVA: diva2:820535
Conference
Conference on Photonic Therapeutics and Diagnostics XI
Available from: 2015-06-12 Created: 2015-06-12 Last updated: 2015-06-12

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Fridberger, Anders
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Division of Cell BiologyFaculty of Medicine and Health Sciences
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