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Controlling Epileptiform Activity with Organic Electronic Ion Pumps
Aix Marseille University, France; INSERM, France.
Ecole National Super Mines, France.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
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2015 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 27, no 20, 3138-3144 p.Article in journal (Refereed) Published
Abstract [en]

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Place, publisher, year, edition, pages
Wiley-VCH Verlag , 2015. Vol. 27, no 20, 3138-3144 p.
Keyword [en]
Organic Bioelectronics, Organic Electronic Ion Pump, PEDOT:PSS, Neuroengineering
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-119247DOI: 10.1002/adma.201500482ISI: 000354823600002PubMedID: 25866154OAI: oai:DiVA.org:liu-119247DiVA: diva2:821223
Note

Funding Agencies|European Union [602102]; A*MIDEX [A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS]; Swedish Innovation Office (VINNOVA); Swedish Research Council [621-2011-3517]; Knut and Alice Wallenberg Foundation [2012.0302]; National Science Foundation [DMR-1105253]; ANR [ANR-13-BSV5-0019-01]; Fondation pour la Recherche Medicale [DBS20131128446]; Fondation de lAvenir; Onnesjo Foundation; Region PACA; Microvitae Technologies; Orthogonal, Inc.; Marie Curie Fellowships

Available from: 2015-06-15 Created: 2015-06-12 Last updated: 2017-11-22
In thesis
1. Organic electronics for precise delivery of neurotransmitters
Open this publication in new window or tab >>Organic electronics for precise delivery of neurotransmitters
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Organic electronic materials, that is, carbon-based compounds that conduct electricity, have emerged as candidates for improving the interface between conventional electronics and biological systems. The softness of these materials matches the elasticity of biological tissue better than conventional electronic conductors, allowing better contact to tissue, and the mixed ionic-electronic conductivity can improve the signal transduction between electronic devices and electrically excitable cells. This improved communication between electronics and tissue can significantly enhance, for example, electrical stimulation for therapy and electrical recording for diagnostics.

The ionic conductivity of organic electronic materials makes it possible to achieve ion-specific ionic currents, where the current consists of migration of specific ions. These ions can be charged signalling substances, such as neurotransmitters, that can selectively activate or inhibit cells that contain receptors for these substances. This thesis describes the development of chemical delivery devices, where delivery is based on such ion-specific currents through ionically and electronically conducting polymers. Delivery is controlled by electrical signals, and allows release of controlled amounts of neurotransmitters, or other charged compounds, to micrometer-sized regions.

The aims of the thesis have been to improve spatial control and temporal resolution of chemical delivery, with the ultimate goal of selective interaction with individual cells, and to enable future therapies for disorders of the nervous system. Within the thesis, we show that delivery can alleviate pain through local delivery to specific regions of the spinal cord in an animal model of neuropathic pain, and that epilepsy-related signalling can be suppressed in vitro. We also integrate the delivery device with electrodes for sensing, to allow simultaneous electrical recording and delivery at the same position. Finally, we improve the delay from electrical signal to chemical delivery, approaching the time domain of synaptic signaling, and construct devices with several individually controlled release sites.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2016. 108 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1817
National Category
Textile, Rubber and Polymeric Materials Condensed Matter Physics Biomedical Laboratory Science/Technology Materials Chemistry Neurosciences
Identifiers
urn:nbn:se:liu:diva-133164 (URN)10.3384/diss.diva-133164 (DOI)978-91-7685-616-1 (ISBN)
Public defence
2017-01-11, Kåkenhus sal K3 (Önnesjösalen), Linköpings Universitet, Norrköping, 10:00 (English)
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Supervisors
Available from: 2016-12-12 Created: 2016-12-12 Last updated: 2017-02-03Bibliographically approved

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Kergoat, LoigJonsson, AmandaArbring, Sjöström, TheresiaSimon, DanielBerggren, Magnus

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