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Skin microcirculation in healthy term newborn infants - assessment of morphology, perfusion and oxygenation
Oslo University Hospital, Norway; University of Oslo, Norway.
Oslo University Hospital, Norway; University of Oslo, Norway.
University of Oslo, Norway; Oslo University Hospital, Norway.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. Oslo University Hospital, Norway.
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2015 (English)In: Clinical hemorheology and microcirculation, ISSN 1386-0291, Vol. 59, no 4, 309-322 p.Article in journal (Refereed) Published
Abstract [en]

Despite microcirculations fundamental role, assessments of its function are limited. We explored the applicability of Computer Assisted Video Microscope (CAVM), Laser Doppler Perfusion Measurements (LDPM) and Diffuse Reflectance Spectroscopy (DRS) to study skin microvascular morphology, perfusion and oxygen saturation in twenty-five healthy newborns day 1-3 of life. Results: Day 1-3 (mean (SD)): Microvascular density (CAVM; number of microvessels crossing a grid of lines/mm line, c/mm): Chest: 11.3 (1.5), 11.0 (1.7), 10.7 (1.6). Hand: 13.2 (2.0), 13.2 (1.9), 12.4 (1.6). Capillary density was significantly higher in the hand than in the chest each day (p less than 0.001). Perfusion (LDPM; arbitrary units): Chest: 109.1 (26.0), 101.4 (24.6), 100.8 (25.3). Hand: 58.9 (17.5), 54.3 (15.8), 46.9 (14.8). Perfusion was significantly higher in the chest than in the hand each day (p less than 0.01). Microvascular oxygen saturation (DRS; %): Chest: 88.1 (5.2), 87.8 (10.0), 86.7 (9.0). Hand: 79.9 (15.2), 82.7 (11.8), 82.2 (12.1) (p less than 0.05). Capillary flow velocities (CAVM) were similar in the chest and hand: 60-70% capillaries had "continuous high flow" and 30-40% "continuous low flow". Multimodal skin microvascular assessments with CAVM, LDPM and DRS are feasible with reproducible data in newborns. The hand has lower perfusion, higher capillary density and higher oxygen extraction than the chest.

Place, publisher, year, edition, pages
IOS Press , 2015. Vol. 59, no 4, 309-322 p.
Keyword [en]
Diffuse reflectance spectroscopy; Laser Doppler; microcirculation; skin microcirculation; video microscopy
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:liu:diva-119597DOI: 10.3233/CH-131764ISI: 000355201300003PubMedID: 24002120OAI: oai:DiVA.org:liu-119597DiVA: diva2:824804
Available from: 2015-06-22 Created: 2015-06-22 Last updated: 2015-06-22

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Häggblad, Erik
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Biomedical InstrumentationThe Institute of Technology
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