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Phosphatidylethanol Compared with Other Blood Tests as a Biomarker of Moderate Alcohol Consumption in Healthy Volunteers: A Prospective Randomized Study.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Gastroentorology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Skåne University Hospital, Lund.
Skåne University Hospital, Lund.
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2015 (English)In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50, no 4, 399-406 p.Article in journal (Refereed) Published
Abstract [en]

AIM: It is generally agreed that traditional alcohol biomarkers lack in sensitivity to detect hazardous alcohol consumption. The present study was undertaken to evaluate the ability of phosphatidylethanol (PEth) and traditional alcohol markers to detect moderate alcohol consumption and to distinguish between moderate alcohol consumption and abstinence.

METHODS: Forty-four subjects, 32 females and 12 males, were included in the study. They were randomized to alcohol abstention or to alcohol consumption. Female participants consumed 150 ml of red wine (equivalent to 16 g of alcohol) per 24 h and the male participants double the amount. The study lasted for 3 months. Blood samples were drawn at the start and at the end of the study period. Blood samples were analysed for PEth, carbohydrate-deficient transferrin (CDT), mean corpuscular volume (MCV), γ-glutamyltransferase (GGT), aspartate aminotransferase (AST) and alanine aminotransferase (ALT).

RESULTS: ROC curves for the various biochemical markers were plotted in order to assess their ability to discriminate between abstention and moderate daily consumption of alcohol. PEth and CDT were the only markers with AUROCs significantly higher than 0.5, and PEth was detected in all participants randomized to alcohol consumption.

CONCLUSION: PEth was the only marker that could detect moderate intake and the present results also indicate that PEth probably can distinguish moderate alcohol consumption from abstinence.

Place, publisher, year, edition, pages
2015. Vol. 50, no 4, 399-406 p.
National Category
Substance Abuse
URN: urn:nbn:se:liu:diva-119707DOI: 10.1093/alcalc/agv038ISI: 000357867100005PubMedID: 25882743OAI: diva2:826157
Available from: 2015-06-24 Created: 2015-06-24 Last updated: 2016-04-12

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Kechagias, StergiosKronstrand, RobertKågedal, BertilNystrom, Fredrik H
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of GastroentorologyDivision of Microbiology and Molecular MedicineDivision of Drug ResearchDepartment of Clinical ChemistryDepartment of Endocrinology
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