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Postmortem MR quantification of the heart for characterization and differentiation of ischaemic myocardial lesions
University of Bern, Switzerland.
University of Bern, Switzerland.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0002-9446-6981
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
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2015 (English)In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 25, no 7, 2067-2073 p.Article in journal (Refereed) Published
Abstract [en]

Recently, an MRI quantification sequence has been developed which can be used to acquire T1- and T2-relaxation times as well as proton density (PD) values. Those three quantitative values can be used to describe soft tissue in an objective manner. The purpose of this study was to investigate the applicability of quantitative cardiac MRI for characterization and differentiation of ischaemic myocardial lesions of different age. Fifty post-mortem short axis cardiac 3 T MR examinations have been quantified using a quantification sequence. Myocardial lesions were identified according to histology and appearance in MRI images. Ischaemic lesions were assessed for mean T1-, T2- and proton density values. Quantitative values were plotted in a 3D-coordinate system to investigate the clustering of ischaemic myocardial lesions. A total of 16 myocardial lesions detected in MRI images were histologically characterized as acute lesions (n = 8) with perifocal oedema (n = 8), subacute lesions (n = 6) and chronic lesions (n = 2). In a 3D plot comprising the combined quantitative values of T1, T2 and PD, the clusters of all investigated lesions could be well differentiated from each other. Post-mortem quantitative cardiac MRI is feasible for characterization and discrimination of different age stages of myocardial infarction. aEuro cent MR quantification is feasible for characterization of different stages of myocardial infarction. aEuro cent The results provide the base for computer-aided MRI cardiac infarction diagnosis. aEuro cent Diagnostic criteria may also be applied for living patients.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2015. Vol. 25, no 7, 2067-2073 p.
Keyword [en]
Post-mortem quantitative magnetic resonance imaging; Myocardial infarction; Ischaemia; Left ventricular; Post-mortem cardiac imaging
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-119784DOI: 10.1007/s00330-014-3582-2ISI: 000355755300026PubMedID: 25591749OAI: oai:DiVA.org:liu-119784DiVA: diva2:827282
Available from: 2015-06-26 Created: 2015-06-26 Last updated: 2016-04-25Bibliographically approved

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Persson, AndersWarntjes, Marcel Jan Bertus
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Center for Medical Image Science and Visualization (CMIV)Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingDivision of Cardiovascular MedicineFaculty of Health SciencesDepartment of Clinical Physiology in Linköping
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European Radiology
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