liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Outcome and Treatment of Elderly Patients with ANCA-Associated Vasculitis
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Nephrology.
University College London Centre for Nephrology, Royal Free Hospital, London, United Kingdom.
Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden; Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, United Kingdom.
Charles Univ Prague, Fac Med 1, Dept Nephrol, Prague, Czech Republic, Gen Univ Hosp, Prague, Czech Republic.
Show others and affiliations
2015 (English)In: Clinical journal of the American Society of Nephrology : CJASN, ISSN 1555-905X, Vol. 10, no 7, 1128-1135 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND OBJECTIVES: ANCA-associated vasculitis is commonly found in elderly patients, but there are few data concerning outcome and treatment in the highest age groups.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive patients (N=151) presenting between 1997 and 2009 were retrospectively included from local registries in six centers in Sweden, the United Kingdom, and the Czech Republic if diagnosed with microscopic polyangiitis or granulomatosis with polyangiitis at age ≥75 years during the study period. Patients were followed until 2 years from diagnosis or death. Data on survival and renal function were analyzed with respect to age, sex, ANCA specificity, renal function, C-reactive protein, comorbidities, and Birmingham Vasculitis Activity Score at diagnosis as well as treatment during the first month.

RESULTS: Median follow-up was 730 days (interquartile range, 244-730). Overall 1-year survival was 71.5% and 2-year survival was 64.6%. Older age, higher creatinine, and lower Birmingham Vasculitis Activity Score were associated with higher mortality in multivariable analysis. Patients who were not treated with standard immunosuppressive therapy had significantly worse survival. Renal survival was 74.8% at 1 year. No new cases of ESRD occurred during the second year. High creatinine at diagnosis was the only significant predictor of renal survival in multivariable analysis.

CONCLUSIONS: ANCA-associated vasculitis is a disease with substantial mortality and morbidity among elderly patients. This study showed a better prognosis for those who received immunosuppressive treatment and those who were diagnosed before having developed advanced renal insufficiency.

Place, publisher, year, edition, pages
American Society of Nephrology , 2015. Vol. 10, no 7, 1128-1135 p.
Keyword [en]
ANCA, glomerulonephritis, survival, vasculitis
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:liu:diva-119904DOI: 10.2215/CJN.00480115ISI: 000357754200006PubMedID: 26100457OAI: oai:DiVA.org:liu-119904DiVA: diva2:838237
Available from: 2015-06-30 Created: 2015-06-30 Last updated: 2017-02-20

Open Access in DiVA

fulltext(504 kB)1367 downloads
File information
File name FULLTEXT01.pdfFile size 504 kBChecksum SHA-512
fba19621295379aadde7b28e24ed4811da4de14f30e97f43b02f9309a537755e67c14b3698770bc8cf459ef31fdfbee0f1c41791b837fc3df5d8fe3474ab0ce5
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Eriksson, PerSegelmark, Mårten

Search in DiVA

By author/editor
Eriksson, PerSegelmark, Mårten
By organisation
Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of NephrologyDivision of Neuro and Inflammation ScienceDepartment of Rheumatology
Urology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar
Total: 1367 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 160 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf