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Nyttan av farmakogenetik för en mer individualiserad behandling: Exemplet tiopuriner vid inflammatorisk tarmsjukdom och barnleukemi
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-2809-7591
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-7642-9263
Karolinska institutet - Institutionen för medicin Linköping, Sweden Karolinska institutet - Institutionen för medicin Linköping, Sweden..
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
2015 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 112, 1229-1233 p., DF7LArticle in journal (Refereed) Published
Abstract [en]

Thiopurines are chemotherapeutic drugs used for treatment of inflammatory bowel diseases and childhood leukemia. Thiopurine methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism of thiopurines. Individuals lacking TPMT are at increased risk for severe side effects when treated with conventional doses of thiopurines. A research group at the division of drug research at Linköping University is studying thiopurine pharmacogenetics. Since the year 2000, the lab has determined the TPMT status in over 12000 individuals, as an aid to decide thiopurine doses before starting treatment. New knowledge of how genetic factors influence thiopurine treatment effect are anticipated to improve the possibilities for individualization of thiopurine therapy.

Place, publisher, year, edition, pages
Stockholm: Läkartidningen , 2015. Vol. 112, 1229-1233 p., DF7L
National Category
Cancer and Oncology
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URN: urn:nbn:se:liu:diva-119996PubMedID: 26126006OAI: oai:DiVA.org:liu-119996DiVA: diva2:839005
Available from: 2015-07-01 Created: 2015-07-01 Last updated: 2015-08-18

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Lindqvist Appell, MalinMårtensson, Lars-GöranPeterson, Curt
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Division of Drug ResearchFaculty of Medicine and Health SciencesChemistryFaculty of Science & EngineeringDepartment of Oncology
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Läkartidningen
Cancer and Oncology

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